5cfv
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5cfv is ON HOLD Authors: Piepenbrink, K.H., Sundberg, E.J. Description: Fusion of Maltose-binding Protein and PilA from Acinetobacter nosocomialis ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Fusion of Maltose-binding Protein and PilA from Acinetobacter nosocomialis M2== | |
| + | <StructureSection load='5cfv' size='340' side='right'caption='[[5cfv]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5cfv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_nosocomialis_M2 Acinetobacter nosocomialis M2] and [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CFV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CFV FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cfv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cfv OCA], [https://pdbe.org/5cfv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cfv RCSB], [https://www.ebi.ac.uk/pdbsum/5cfv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cfv ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Acinetobacter baumannii is a Gram-negative coccobacillus found primarily in hospital settings that has recently emerged as a source of hospital-acquired infections. A. baumannii expresses a variety of virulence factors, including type IV pili, a bacterial extracellular appendage often essential for attachment to host cells. Here, we report the high-resolution structures of the major pilin subunit, PilA, from three Acinetobacter strains, demonstrating that A. baumannii subsets produce morphologically distinct type IV pilin glycoproteins. We examine the consequences of this heterogeneity for protein folding and assembly as well as host-cell adhesion by Acinetobacter. Comparisons of genomic and structural data with pilin proteins from other species of soil gammaproteobacteria suggest that these structural differences stem from evolutionary pressure which has resulted in three distinct classes of type IVa pilins, each found in multiple species. | ||
| - | + | Structural diversity in the type IV pili of multidrug-resistant Acinetobacter.,Piepenbrink KJ, Lillehoj EP, Harding CM, Labonte JW, Zuo X, Rapp CA, Munson RS Jr, Goldblum SE, Feldman MF, Gray JJ, Sundberg EJ J Biol Chem. 2016 Sep 15. pii: jbc.M116.751099. PMID:27634041<ref>PMID:27634041</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Piepenbrink | + | <div class="pdbe-citations 5cfv" style="background-color:#fffaf0;"></div> |
| - | [[Category: Sundberg | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Acinetobacter nosocomialis M2]] | ||
| + | [[Category: Escherichia coli K-12]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Piepenbrink KH]] | ||
| + | [[Category: Sundberg EJ]] | ||
Current revision
Fusion of Maltose-binding Protein and PilA from Acinetobacter nosocomialis M2
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