4y01
From Proteopedia
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==Crystal structure of dipeptidyl peptidase 11 (DPP11) from Porphyromonas gingivalis== | ==Crystal structure of dipeptidyl peptidase 11 (DPP11) from Porphyromonas gingivalis== | ||
| - | <StructureSection load='4y01' size='340' side='right' caption='[[4y01]], [[Resolution|resolution]] 2.46Å' scene=''> | + | <StructureSection load='4y01' size='340' side='right'caption='[[4y01]], [[Resolution|resolution]] 2.46Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4y01]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y01 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4y01]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Porphyromonas_gingivalis Porphyromonas gingivalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y01 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y01 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.46Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y01 OCA], [https://pdbe.org/4y01 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y01 RCSB], [https://www.ebi.ac.uk/pdbsum/4y01 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y01 ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DPP11_PORG3 DPP11_PORG3] Catalyzes the removal of dipeptides from the N-terminus of oligopeptides. Shows a strict specificity for acidic residues (Asp or Glu) in the P1 position, and has a hydrophobic residue preference at the P2 position. Preferentially cleaves the synthetic substrate Leu-Asp-methylcoumaryl-7-amide (Leu-Asp-MCA) as compared to Leu-Glu-MCA. Is involved in amino acid metabolism and bacterial growth of asaccharolytic P.gingivalis, that utilizes amino acids from extracellular proteinaceous nutrients as energy and carbon sources.<ref>PMID:21896480</ref> <ref>PMID:23246913</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 4y01" style="background-color:#fffaf0;"></div> | ||
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| + | ==See Also== | ||
| + | *[[Dipeptidyl peptidase 3D structures|Dipeptidyl peptidase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Fujimoto | + | [[Category: Large Structures]] |
| - | [[Category: Iizuka | + | [[Category: Porphyromonas gingivalis]] |
| - | [[Category: Nonaka | + | [[Category: Fujimoto M]] |
| - | [[Category: Ogasawara | + | [[Category: Iizuka I]] |
| - | [[Category: Roppongi | + | [[Category: Nonaka T]] |
| - | [[Category: Sakamoto | + | [[Category: Ogasawara W]] |
| - | [[Category: Suzuki | + | [[Category: Roppongi S]] |
| - | [[Category: Tanaka | + | [[Category: Sakamoto Y]] |
| - | [[Category: Tateoka | + | [[Category: Suzuki Y]] |
| - | + | [[Category: Tanaka N]] | |
| + | [[Category: Tateoka C]] | ||
Current revision
Crystal structure of dipeptidyl peptidase 11 (DPP11) from Porphyromonas gingivalis
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