Rho guanine nucleotide exchange factor
From Proteopedia
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| - | <StructureSection load='3kz1' size='340' side='right' caption='Human Rho guanine nucleotide exchange factor 11 DH/PH domain (grey | + | <StructureSection load='3kz1' size='340' side='right' caption='Human Rho guanine nucleotide exchange factor 11 DH/PH domain (grey) complex with transforming protein RhoA (cyan), GSP and Mg+2 ion (green) (PDB code [[3kz1]])' scene=''> |
| - | + | __TOC__ | |
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== Function == | == Function == | ||
| + | '''Rho guanine nucleotide exchange factor''' (GEF) stimulate the exchange of the inactive GDP-bound GTPase to its active GTP-bound form. Binding of GEF to GDP-GTPase catalyzes the dissociation of GDP from the protein<ref>PMID:23303910</ref>. GEF domains include the catalytic DH/PH (Dbl Homology/Pleckstrin Homology) domain; the CH (Calponin Homology) domain is believed to be involved in calcium regulation; the SH3 domain interacts with proline-rich sequences. | ||
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| + | *'''Rho guanine nucleotide exchange factor 1''' binds to G proteins and stimulate Rho-dependent signals.<br /> | ||
| + | *'''Rho guanine nucleotide exchange factor 3''' acts on RHOA and RHOB involved in bone biology.<br /> | ||
| + | *'''Rho guanine nucleotide exchange factor 6''' and '''Rho guanine nucleotide exchange factor 7''' act on Rac1.<br /> | ||
| + | *'''Rho guanine nucleotide exchange factor 9''' mutations involved in developmental and epileptic encephalopathy<ref>PMID:35638461</ref>. | ||
| + | *'''Rho guanine nucleotide exchange factor 11''' mediates Rho-myosin light chain signaling pathways at cell-cell junctions<ref>PMID:22665792</ref>. | ||
| + | *'''Rho guanine nucleotide exchange factor 18''' regulates tissue architecture and function via RhoA activation<ref>PMID:23698346</ref>. | ||
| + | *'''Rho guanine nucleotide exchange factor 25''' involved in contraction of vascular smooth muscle. | ||
== Disease == | == Disease == | ||
| - | + | Increased GEF activity is involved in cancer cell proliferation by affecting Rho GTPases <ref>PMID:24037532</ref>. | |
| - | == | + | == 3D Structures of Rho guanine nucleotide exchange factor == |
| - | + | [[Rho guanine nucleotide exchange factor 3D structures]] | |
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</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of Rho guanine nucleotide exchange factor == | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *Rho guanine nucleotide exchange factor 1 (P115-RhoGEF) | ||
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| - | **[[1iap]] – hRho N terminal - human<br /> | ||
| - | **[[3odo]], [[3odw]], [[3odx]] – hRho DH/PH domain <br /> | ||
| - | **[[3p6a]] – hRho DH/PH domain (mutant)<br /> | ||
| - | **[[1shz]], [[3ab3]] – hRho N terminal + guanine nucleotide-binding protein<br /> | ||
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| - | *Rho guanine nucleotide exchange factor 4 (Asef) | ||
| - | |||
| - | **[[2dx1]], [[2pz1]] – hRho <br /> | ||
| - | **[[3nmx]], [[3nmz]] – hRho + APC variant protein<br /> | ||
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| - | *Rho guanine nucleotide exchange factor 6 | ||
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| - | **[[1ujy]] – hRho SH3 domain - NMR<br /> | ||
| - | **[[1wyr]] – hRho CH domain - NMR<br /> | ||
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| - | *Rho guanine nucleotide exchange factor 7 (β-PIX) | ||
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| - | **[[1by1]] – hRho DH domain - NMR<br /> | ||
| - | **[[2l3g]] – hRho CH domain - NMR<br /> | ||
| - | **[[2esw]] – Rho SH3 domain – mouse<br /> | ||
| - | **[[2g6f]] – rRho SH3 domain – rat<br /> | ||
| - | **[[2w6b]] – rRho coiled-coil domain <br /> | ||
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| - | *Rho guanine nucleotide exchange factor 7 complex with peptide | ||
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| - | **[[2ak5]] – hRho SH3 domain + CBL-b peptide <br /> | ||
| - | **[[2df6]] – hRho SH3 domain + PAK-1 peptide <br /> | ||
| - | **[[1zsg]] – hRho residues 179-243 + PAK-1 peptide – NMR<br /> | ||
| - | **[[2p4r]] – rRho SH3 domain + E3 ubiquitin protein ligase peptide <br /> | ||
| - | **[[3l4f]] – rRho coiled-coil domain + SHANK1 PDZ domain <br /> | ||
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| - | *Rho guanine nucleotide exchange factor 8 (PRONE8) | ||
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| - | **[[2ntx]] – AtRho PRONE domain – ''Arabidopasis thaliana''<br /> | ||
| - | **[[2wbl]] – AtRho PRONE domain + GTPase ROP7 <br /> | ||
| - | **[[2nty]] – AtRho PRONE domain + GTPase ROP4 + GDP <br /> | ||
| - | **[[3eo2]] – hRho residues 161-373 <br /> | ||
| - | **[[4xh9]] – hRho DH/PH domain + transforming protein RhoA <br /> | ||
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| - | *Rho guanine nucleotide exchange factor 9 (collybistin) | ||
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| - | **[[2ysq]] – hRho SH3 domain - NMR<br /> | ||
| - | **[[4mt6]], [[4mt7]] – rRho (mutant)<br /> | ||
| - | **[[2dfk]] – rRho + CDC42 <br /> | ||
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| - | *Rho guanine nucleotide exchange factor 11 | ||
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| - | **[[2dls]] – hRho PDZ domain - NMR<br /> | ||
| - | **[[3kz1]], [[3t06]] – hRho DH/PH domain + transforming protein RhoA <br /> | ||
| - | **[[1xcg]] – hRho DH/PH domain + transforming protein RhoA - NMR<br /> | ||
| - | **[[3cx6]] – rRho RGS domain + guanine nucleotide-binding protein <br /> | ||
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| - | *Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) | ||
| - | |||
| - | **[[1txd]] – hRho DH/PH domain <br /> | ||
| - | **[[2omj]] – hRho PDZ domain <br /> | ||
| - | **[[1x86]] – hRho DH/PH domain (mutant) + transforming protein RhoA <br /> | ||
| - | **[[2os6]] – hRho PDZ domain + plexin peptide – NMR<br /> | ||
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| - | *Rho guanine nucleotide exchange factor 16 | ||
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| - | **[[1x6b]] – hRho SH3 domain - NMR<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
| + | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Cherfils J, Zeghouf M. Regulation of small GTPases by GEFs, GAPs, and GDIs. Physiol Rev. 2013 Jan;93(1):269-309. doi: 10.1152/physrev.00003.2012. PMID:23303910 doi:http://dx.doi.org/10.1152/physrev.00003.2012
- ↑ Yang H, Liao H, Gan S, Xiao T, Wu L. ARHGEF9 gene variant leads to developmental and epileptic encephalopathy: Genotypic phenotype analysis and treatment exploration. Mol Genet Genomic Med. 2022 Jul;10(7):e1967. PMID:35638461 doi:10.1002/mgg3.1967
- ↑ Itoh M, Tsukita S, Yamazaki Y, Sugimoto H. Rho GTP exchange factor ARHGEF11 regulates the integrity of epithelial junctions by connecting ZO-1 and RhoA-myosin II signaling. Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9905-10. PMID:22665792 doi:10.1073/pnas.1115063109
- ↑ Herder C, Swiercz JM, Müller C, Peravali R, Quiring R, Offermanns S, Wittbrodt J, Loosli F. ArhGEF18 regulates RhoA-Rock2 signaling to maintain neuro-epithelial apico-basal polarity and proliferation. Development. 2013 Jul;140(13):2787-97. PMID:23698346 doi:10.1242/dev.096487
- ↑ Cook DR, Rossman KL, Der CJ. Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease. Oncogene. 2014 Jul 31;33(31):4021-35. doi: 10.1038/onc.2013.362. Epub 2013 Sep, 16. PMID:24037532 doi:http://dx.doi.org/10.1038/onc.2013.362
