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4v2a

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==human Unc5A ectodomain==
==human Unc5A ectodomain==
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<StructureSection load='4v2a' size='340' side='right' caption='[[4v2a]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='4v2a' size='340' side='right'caption='[[4v2a]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4v2a]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V2A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V2A FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4v2a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V2A FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4v2b|4v2b]], [[4v2c|4v2c]], [[4v2d|4v2d]], [[4v2e|4v2e]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v2a OCA], [https://pdbe.org/4v2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v2a RCSB], [https://www.ebi.ac.uk/pdbsum/4v2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v2a ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v2a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4v2a RCSB], [http://www.ebi.ac.uk/pdbsum/4v2a PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/UNC5A_HUMAN UNC5A_HUMAN]] Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
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[https://www.uniprot.org/uniprot/UNC5A_HUMAN UNC5A_HUMAN] Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4v2a" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Acker-Palmer, A]]
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[[Category: Homo sapiens]]
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[[Category: Border, E C]]
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[[Category: Large Structures]]
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[[Category: Cop, F]]
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[[Category: Acker-Palmer A]]
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[[Category: Haertl, R]]
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[[Category: Border EC]]
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[[Category: Harlos, K]]
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[[Category: Cop F]]
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[[Category: Jones, E Y]]
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[[Category: Haertl R]]
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[[Category: Klein, R]]
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[[Category: Harlos K]]
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[[Category: Nagel, D]]
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[[Category: Jones EY]]
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[[Category: Ruff, T]]
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[[Category: Klein R]]
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[[Category: Seiradake, E]]
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[[Category: Nagel D]]
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[[Category: Seyit-Bremer, G]]
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[[Category: Ruff T]]
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[[Category: Toro, D del]]
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[[Category: Seiradake E]]
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[[Category: Apoptosis]]
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[[Category: Seyit-Bremer G]]
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[[Category: Flrt]]
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[[Category: Del Toro D]]
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[[Category: Netrin receptor]]
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[[Category: Unc5a]]
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[[Category: Uncoordinated-5]]
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Current revision

human Unc5A ectodomain

PDB ID 4v2a

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