5cfo
From Proteopedia
(Difference between revisions)
| (6 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of anemone STING (Nematostella vectensis) in apo 'rotated' open conformation== | |
| + | <StructureSection load='5cfo' size='340' side='right'caption='[[5cfo]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5cfo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Nematostella_vectensis Nematostella vectensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CFO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CFO FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.102Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cfo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cfo OCA], [https://pdbe.org/5cfo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cfo RCSB], [https://www.ebi.ac.uk/pdbsum/5cfo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cfo ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/STING_NEMVE STING_NEMVE] Sensor of cytosolic DNA from bacteria and viruses that promotes autophagy (PubMed:30842662). Acts by recognizing and binding cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA in the cytosol (PubMed:26300263, PubMed:30842662). Following cGAMP-binding, promotes the formation of autophagosomes, leading to target cytosolic DNA for degradation by the lysosome (PubMed:30842662). Exhibits guanine base-specific ligand recognition. Binds 3'-3'linked cGAMP, 2'-3' linked cGAMP and 3'-3' linked c-di-GMP with much greater affinity as compared to 3'-3' linked c-di-AMP (PubMed:26300263). Lacks the C-terminal tail (CTT) found in mammalian orthologs which is essential for interferon signaling (PubMed:26300263).<ref>PMID:26300263</ref> <ref>PMID:30842662</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Stimulator of interferon genes protein|Stimulator of interferon genes protein]] | |
| - | + | *[[Stimulator of interferon genes protein 3D structures|Stimulator of interferon genes protein 3D structures]] | |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Nematostella vectensis]] |
| - | [[Category: | + | [[Category: Berger JM]] |
| + | [[Category: Doudna JA]] | ||
| + | [[Category: Kranzusch PJ]] | ||
| + | [[Category: Lee ASY]] | ||
| + | [[Category: Vance RE]] | ||
| + | [[Category: Wilson SC]] | ||
Current revision
Crystal structure of anemone STING (Nematostella vectensis) in apo 'rotated' open conformation
| |||||||||||
