5cit

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'''Unreleased structure'''
 
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The entry 5cit is ON HOLD
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==Ran GDP wild type monoclinic crystal form==
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<StructureSection load='5cit' size='340' side='right'caption='[[5cit]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5cit]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CIT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CIT FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cit OCA], [https://pdbe.org/5cit PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cit RCSB], [https://www.ebi.ac.uk/pdbsum/5cit PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cit ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref>
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Authors: Vetter, I.R., Brucker, S.
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==See Also==
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
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Description: Ran GDP wild type monoclinic crystal form
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Brucker, S]]
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__TOC__
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[[Category: Vetter, I.R]]
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Brucker S]]
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[[Category: Vetter IR]]

Current revision

Ran GDP wild type monoclinic crystal form

PDB ID 5cit

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