5cj2

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(New page: '''Unreleased structure''' The entry 5cj2 is ON HOLD Authors: Vetter, I.R., Brucker, S. Description: Ran GDP Y39A mutant triclinic crystal form Category: Unreleased Structures [[Ca...)
Current revision (07:21, 1 May 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 5cj2 is ON HOLD
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==Ran GDP Y39A mutant triclinic crystal form==
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<StructureSection load='5cj2' size='340' side='right'caption='[[5cj2]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5cj2]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CJ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CJ2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cj2 OCA], [https://pdbe.org/5cj2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cj2 RCSB], [https://www.ebi.ac.uk/pdbsum/5cj2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cj2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref>
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Authors: Vetter, I.R., Brucker, S.
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==See Also==
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
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Description: Ran GDP Y39A mutant triclinic crystal form
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Brucker, S]]
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__TOC__
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[[Category: Vetter, I.R]]
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Brucker S]]
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[[Category: Vetter IR]]

Current revision

Ran GDP Y39A mutant triclinic crystal form

PDB ID 5cj2

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