5cmq
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Zn-bound Human H-Ferritin variant 122H-delta C-star== | |
| + | <StructureSection load='5cmq' size='340' side='right'caption='[[5cmq]], [[Resolution|resolution]] 1.94Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5cmq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CMQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CMQ FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.935Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cmq OCA], [https://pdbe.org/5cmq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cmq RCSB], [https://www.ebi.ac.uk/pdbsum/5cmq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cmq ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FRIH_HUMAN FRIH_HUMAN] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | We describe here the construction of a three-dimensional, porous, crystalline framework formed by spherical protein nodes that assemble into a prescribed lattice arrangement through metal-organic linker-directed interactions. The octahedral iron storage en-zyme, ferritin, was engineered in its C3 symmetric pores with tripodal Zn coordination sites. Dynamic light scat-tering and crystallographic studies established that this Zn-ferritin construct could robustly self-assemble into the desired bcc-type crystals upon coordination of a ditopic linker bearing hydroxamic acid functional groups. This system represents the first example of a ternary protein-metal-organic crystalline framework whose formation is fully dependent on each of its three components. | ||
| - | + | A Metal Organic Framework with Spherical Protein Nodes: Rational Chemical Design of 3D Protein Crystals.,Sontz PA, Bailey JB, Ahn S, Tezcan FA J Am Chem Soc. 2015 Aug 25. PMID:26305584<ref>PMID:26305584</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 5cmq" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | |
| - | [[Category: Bailey | + | ==See Also== |
| - | [[Category: | + | *[[Ferritin 3D structures|Ferritin 3D structures]] |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ahn S]] | ||
| + | [[Category: Bailey JB]] | ||
| + | [[Category: Sontz PA]] | ||
| + | [[Category: Tezcan FA]] | ||
Current revision
Crystal Structure of Zn-bound Human H-Ferritin variant 122H-delta C-star
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