4qhc

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==Structure of M.Tuberculosis Betalactamase (Blac) with inhibitor having novel mechanism==
==Structure of M.Tuberculosis Betalactamase (Blac) with inhibitor having novel mechanism==
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<StructureSection load='4qhc' size='340' side='right' caption='[[4qhc]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='4qhc' size='340' side='right'caption='[[4qhc]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4qhc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QHC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QHC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4qhc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QHC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QHC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=33V:(3R,6R,7S)-7-[(2R,3AR)-HEXAHYDROPYRAZOLO[1,5-C][1,3]THIAZIN-2-YL]-6-(HYDROXYMETHYL)-1,4-THIAZEPANE-3-CARBOXYLIC+ACID'>33V</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.899&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4df6|4df6]], [[4q8i|4q8i]], [[4qb8|4qb8]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=33V:(3R,6R,7S)-7-[(2R,3AR)-HEXAHYDROPYRAZOLO[1,5-C][1,3]THIAZIN-2-YL]-6-(HYDROXYMETHYL)-1,4-THIAZEPANE-3-CARBOXYLIC+ACID'>33V</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qhc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qhc OCA], [https://pdbe.org/4qhc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qhc RCSB], [https://www.ebi.ac.uk/pdbsum/4qhc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qhc ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qhc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qhc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qhc RCSB], [http://www.ebi.ac.uk/pdbsum/4qhc PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BLAC_MYCTU BLAC_MYCTU]
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==See Also==
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Beta-lactamase]]
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[[Category: Large Structures]]
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[[Category: Blanchard, J]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Hazra, S]]
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[[Category: Blanchard J]]
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[[Category: 3-layer sandwich]]
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[[Category: Hazra S]]
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[[Category: Beta-lactamase super family]]
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[[Category: Betalactam]]
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[[Category: Betalactamase]]
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[[Category: Dd-peptidase]]
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[[Category: Drug resistance]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Novel mechanism]]
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[[Category: Penem]]
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[[Category: Qm/mm]]
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Current revision

Structure of M.Tuberculosis Betalactamase (Blac) with inhibitor having novel mechanism

PDB ID 4qhc

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