TNF receptor-associated factor
From Proteopedia
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(New page: <StructureSection load='1d01' size='340' side='right' caption='Human TRAF2 TRAF domain complex with CD30 peptide (PDB code 1d01)' scene=''> '''TNF receptor-associated factor''' (TRAF)...) |
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| - | + | <StructureSection load='' size='350' side='right' caption='Human TRAF2 TRAF domain (green) complex with TNFR type 1 associated death domain protein TRADD (deepskyblue) (PDB code [[1f3v]])' scene='70/708054/Cv/1'> | |
| - | <StructureSection load=' | + | __TOC__ |
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== Function == | == Function == | ||
| - | + | '''TNF receptor-associated factor''' (TRAF) are signal transducers and are involved in regulation of apoptosis, inflammation and antiviral response. There are 7 known TRAF proteins. All TRAF proteins share a C-terminal homology region named TRAF domain which can bind the cytoplasmic domain of receptors and other TRAF proteins<ref>PMID:11607847</ref>. | |
| - | + | *'''TRAF1''' is the only TRAF which does not have N-terminal RING and zinc finger motifs. | |
| - | + | *'''TRAF2, TRAF5 and TRAF6''' mediate activation of NF-κB and JNK. | |
| - | + | *'''TRAF3''' mediates some innate immune receptor signals and regulates some post-translational modifications<ref>PMID:22017431</ref>. | |
| + | *'''TRAF4''' is a binding partner of glycoproteins in platelets<ref>PMID:20946164</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
| + | The interaction of TRAF2 with the adaptor protein TRADD is <scene name='70/708054/Cv/4'>bipartite with one part containing mainly hydrophobic interactions while the second part contains mainly polar interactions</scene><ref>PMID:10892748</ref>. {{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}} | ||
| + | == 3D Structures of TNF receptor-associated factor == | ||
| + | [[TNF receptor-associated factor 3D structures]] | ||
</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of TNF receptor-associated factor == | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *TRAF1 | ||
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| - | **[[3m0d]] – hTRAF1 residues 266-329 + hTRAF2 + cIAP2 - human<br /> | ||
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| - | *TRAF2 | ||
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| - | **[[1ca4]] – hTRAF2 TRAF domain <br /> | ||
| - | **[[3knv]] – hTRAF2 RING+zinc finger 1 domains <br /> | ||
| - | **[[3m06]] – hTRAF2 residues 266-329 <br /> | ||
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| - | *TRAF2 complex with peptide | ||
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| - | **[[1ca9]] – hTRAF2 TRAF domain + TNF-R2 peptide<br /> | ||
| - | **[[1qsc]], [[1d00]], [[1czz]] – hTRAF2 TRAF domain + CD40 receptor peptide<br /> | ||
| - | **[[1d01]] – hTRAF2 TRAF domain + CD30 peptide<br /> | ||
| - | **[[1czy]] – hTRAF2 TRAF domain + latent membrane protein peptide<br /> | ||
| - | **[[1d0a]] – hTRAF2 TRAF domain + OX40L receptor peptide<br /> | ||
| - | **[[1d0j]] – hTRAF2 TRAF domain + 4-1BB ligand receptor peptide<br /> | ||
| - | **[[1f3v]] – hTRAF2 TRAF domain + TRADD N terminal<br /> | ||
| - | **[[3m0a]] – hTRAF2 residues 266-329 + cIAP2<br /> | ||
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| - | *TRAF6 | ||
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| - | **[[1lb4]] – hTRAF6 TRAF domain <br /> | ||
| - | **[[2jmd]], [[2eci]] – hTRAF6 RING domain - NMR<br /> | ||
| - | **[[3hcs]] – hTRAF6 RING+zinc finger 1-3 domains <br /> | ||
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| - | *TRAF6 complex with peptide | ||
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| - | **[[1lb5]] – hTRAF6 TRAF domain + RANK peptide<br /> | ||
| - | **[[1lb6]] – hTRAF6 TRAF domain + CD40 antigen peptide<br /> | ||
| - | **[[3hct]], [[3hcu]] – hTRAF6 RING+zinc finger 1 domains + ubiquitin-conjugating enzyme E2<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
| + | [[Category:Topic Page]] | ||
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References
- ↑ Bradley JR, Pober JS. Tumor necrosis factor receptor-associated factors (TRAFs). Oncogene. 2001 Oct 1;20(44):6482-91. PMID:11607847 doi:http://dx.doi.org/10.1038/sj.onc.1204788
- ↑ Hildebrand JM, Yi Z, Buchta CM, Poovassery J, Stunz LL, Bishop GA. Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions. Immunol Rev. 2011 Nov;244(1):55-74. doi: 10.1111/j.1600-065X.2011.01055.x. PMID:22017431 doi:http://dx.doi.org/10.1111/j.1600-065X.2011.01055.x
- ↑ Arthur JF, Shen Y, Gardiner EE, Coleman L, Murphy D, Kenny D, Andrews RK, Berndt MC. TNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets. J Thromb Haemost. 2011 Jan;9(1):163-72. doi: 10.1111/j.1538-7836.2010.04091.x. PMID:20946164 doi:http://dx.doi.org/10.1111/j.1538-7836.2010.04091.x
- ↑ Park YC, Ye H, Hsia C, Segal D, Rich RL, Liou HC, Myszka DG, Wu H. A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction. Cell. 2000 Jun 23;101(7):777-87. PMID:10892748
