4qh6

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==Crystal structure of cruzain with nitrile inhibitor N-(2-AMINOETHYL)-NALPHA-BENZOYL-L-PHENYLALANINAMIDE==
==Crystal structure of cruzain with nitrile inhibitor N-(2-AMINOETHYL)-NALPHA-BENZOYL-L-PHENYLALANINAMIDE==
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<StructureSection load='4qh6' size='340' side='right' caption='[[4qh6]], [[Resolution|resolution]] 3.13&Aring;' scene=''>
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<StructureSection load='4qh6' size='340' side='right'caption='[[4qh6]], [[Resolution|resolution]] 3.13&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4qh6]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QH6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QH6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4qh6]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QH6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QH6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=33L:N-(2-AMINOETHYL)-NALPHA-BENZOYL-L-PHENYLALANINAMIDE'>33L</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.13&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cruzipain Cruzipain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.51 3.4.22.51] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=33L:N-(2-AMINOETHYL)-NALPHA-BENZOYL-L-PHENYLALANINAMIDE'>33L</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qh6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qh6 RCSB], [http://www.ebi.ac.uk/pdbsum/4qh6 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qh6 OCA], [https://pdbe.org/4qh6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qh6 RCSB], [https://www.ebi.ac.uk/pdbsum/4qh6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qh6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CYSP_TRYCR CYSP_TRYCR]] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle.
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[https://www.uniprot.org/uniprot/CYSP_TRYCR CYSP_TRYCR] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4qh6" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Cruzain|Cruzain]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cruzipain]]
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[[Category: Large Structures]]
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[[Category: Fernandes, W B]]
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[[Category: Trypanosoma cruzi]]
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[[Category: McKerrow, J H]]
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[[Category: Fernandes WB]]
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[[Category: Montanari, C A]]
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[[Category: McKerrow JH]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Montanari CA]]
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[[Category: Thiol protease]]
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Current revision

Crystal structure of cruzain with nitrile inhibitor N-(2-AMINOETHYL)-NALPHA-BENZOYL-L-PHENYLALANINAMIDE

PDB ID 4qh6

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