2uvy

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[[Image:2uvy.gif|left|200px]]<br />
 
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<applet load="2uvy" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2uvy, resolution 1.95&Aring;" />
 
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'''STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH METHYL-(4-(9H-PURIN-6-YL)-BENZYL)-AMINE'''<br />
 
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==About this Structure==
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==Structure of PKA-PKB chimera complexed with methyl-(4-(9H-purin-6-yl)- benzyl)-amine==
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2UVY is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with GVI as [http://en.wikipedia.org/wiki/ligand ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2UVY OCA].
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<StructureSection load='2uvy' size='340' side='right'caption='[[2uvy]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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[[Category: Bos taurus]]
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== Structural highlights ==
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[[Category: Protein complex]]
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<table><tr><td colspan='2'>[[2uvy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UVY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UVY FirstGlance]. <br>
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[[Category: Aherne, G.W.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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[[Category: Boyle, R.G.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GVI:N-METHYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE'>GVI</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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[[Category: Collins, I.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uvy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uvy OCA], [https://pdbe.org/2uvy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uvy RCSB], [https://www.ebi.ac.uk/pdbsum/2uvy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uvy ProSAT]</span></td></tr>
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[[Category: Davies, T.G.]]
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</table>
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[[Category: Donald, A.]]
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== Function ==
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[[Category: Garrett, M.D.]]
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[https://www.uniprot.org/uniprot/IPKA_HUMAN IPKA_HUMAN] Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
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[[Category: Hunter, L.J.]]
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== Evolutionary Conservation ==
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[[Category: Mchardy, T.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Rowlands, M.G.]]
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Check<jmol>
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[[Category: GVI]]
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<jmolCheckbox>
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[[Category: atp-binding]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uv/2uvy_consurf.spt"</scriptWhenChecked>
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[[Category: camp]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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[[Category: kinase]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: lipoprotein]]
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</jmolCheckbox>
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[[Category: myristate]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2uvy ConSurf].
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[[Category: nuclear protein]]
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<div style="clear:both"></div>
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[[Category: nucleotide-binding]]
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<div style="background-color:#fffaf0;">
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[[Category: phosphorylation]]
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== Publication Abstract from PubMed ==
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[[Category: protein kinase inhibitor]]
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6-phenylpurines were identified as novel, ATP-competitive inhibitors of protein kinase B (PKB/Akt) from a fragment-based screen and were rapidly progressed to potent compounds using iterative protein-ligand crystallography with a PKA-PKB chimeric protein. An elaborated lead compound showed cell growth inhibition and effects on cellular signaling pathways characteristic of PKB inhibition.
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[[Category: serine/threonine-protein kinase]]
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[[Category: transferase]]
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[[Category: transferase/inhibitor complex]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 14:30:24 2007''
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Rapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based design.,Donald A, McHardy T, Rowlands MG, Hunter LJ, Davies TG, Berdini V, Boyle RG, Aherne GW, Garrett MD, Collins I J Med Chem. 2007 May 17;50(10):2289-92. Epub 2007 Apr 24. PMID:17451235<ref>PMID:17451235</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2uvy" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[CAMP-dependent protein kinase 3D structures|CAMP-dependent protein kinase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bos taurus]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Aherne GW]]
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[[Category: Boyle RG]]
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[[Category: Collins I]]
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[[Category: Davies TG]]
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[[Category: Donald A]]
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[[Category: Garrett MD]]
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[[Category: Hunter LJ]]
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[[Category: McHardy T]]
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[[Category: Rowlands MG]]

Current revision

Structure of PKA-PKB chimera complexed with methyl-(4-(9H-purin-6-yl)- benzyl)-amine

PDB ID 2uvy

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OCA

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