5ay4

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(New page: '''Unreleased structure''' The entry 5ay4 is ON HOLD Authors: Kondo, J., Tada, Y., Dairaku, T., Saneyoshi, H., Okamoto, I., Tanaka, Y., Ono, A. Description: Crystal structure of RNA du...)
Current revision (15:51, 8 November 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 5ay4 is ON HOLD
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==Crystal structure of RNA duplex containing C-C base pairs obtained in the presence of Hg(II)==
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<StructureSection load='5ay4' size='340' side='right'caption='[[5ay4]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5ay4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AY4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AY4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CBR:5-BROMO-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>CBR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ay4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ay4 OCA], [https://pdbe.org/5ay4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ay4 RCSB], [https://www.ebi.ac.uk/pdbsum/5ay4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ay4 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Metallo-base pairs have been extensively studied for applications in nucleic acid-based nanodevices and genetic code expansion. Metallo-base pairs composed of natural nucleobases are attractive because nanodevices containing natural metallo-base pairs can be easily prepared from commercially available sources. Previously, we have reported a crystal structure of a DNA duplex containing THgII T base pairs. Herein, we have determined a high-resolution crystal structure of the second natural metallo-base pair between pyrimidine bases CAgI C formed in an RNA duplex. One AgI occupies the center between two cytosines and forms a CAgI C base pair through N3AgI N3 linear coordination. The CAgI C base pair formation does not disturb the standard A-form conformation of RNA. Since the CAgI C base pair is structurally similar to the canonical Watson-Crick base pairs, it can be a useful building block for structure-based design and fabrication of nucleic acid-based nanodevices.
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Authors: Kondo, J., Tada, Y., Dairaku, T., Saneyoshi, H., Okamoto, I., Tanaka, Y., Ono, A.
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High-Resolution Crystal Structure of Silver(I)-RNA Hybrid Duplex Containing Watson-Crick-like CSilver(I)C Metallo-Base Pairs.,Kondo J, Tada Y, Dairaku T, Saneyoshi H, Okamoto I, Tanaka Y, Ono A Angew Chem Int Ed Engl. 2015 Oct 8. doi: 10.1002/anie.201507894. PMID:26448329<ref>PMID:26448329</ref>
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Description: Crystal structure of RNA duplex containing C-C base pairs obtained in the presence of Hg(II)
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Kondo, J]]
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<div class="pdbe-citations 5ay4" style="background-color:#fffaf0;"></div>
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[[Category: Okamoto, I]]
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== References ==
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[[Category: Tada, Y]]
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<references/>
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[[Category: Ono, A]]
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__TOC__
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[[Category: Saneyoshi, H]]
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</StructureSection>
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[[Category: Dairaku, T]]
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[[Category: Large Structures]]
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[[Category: Tanaka, Y]]
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[[Category: Synthetic construct]]
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[[Category: Dairaku T]]
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[[Category: Kondo J]]
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[[Category: Okamoto I]]
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[[Category: Ono A]]
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[[Category: Saneyoshi H]]
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[[Category: Tada Y]]
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[[Category: Tanaka Y]]

Current revision

Crystal structure of RNA duplex containing C-C base pairs obtained in the presence of Hg(II)

PDB ID 5ay4

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