5cgd
From Proteopedia
(Difference between revisions)
| (3 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| + | |||
==Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator 3-chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile - (HTL14242)== | ==Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator 3-chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile - (HTL14242)== | ||
| - | <StructureSection load='5cgd' size='340' side='right' caption='[[5cgd]], [[Resolution|resolution]] 2.60Å' scene=''> | + | <StructureSection load='5cgd' size='340' side='right'caption='[[5cgd]], [[Resolution|resolution]] 2.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5cgd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CGD OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5cgd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CGD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CGD FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.603Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=51E:3-CHLORO-5-[6-(5-FLUOROPYRIDIN-2-YL)PYRIMIDIN-4-YL]BENZONITRILE'>51E</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cgd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cgd OCA], [https://pdbe.org/5cgd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cgd RCSB], [https://www.ebi.ac.uk/pdbsum/5cgd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cgd ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref> [https://www.uniprot.org/uniprot/GRM5_HUMAN GRM5_HUMAN] Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 18: | Line 18: | ||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 5cgd" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Metabotropic glutamate receptor 3D structures|Metabotropic glutamate receptor 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Escherichia virus T4]] |
| - | [[Category: Aves | + | [[Category: Homo sapiens]] |
| - | [[Category: Bennett | + | [[Category: Large Structures]] |
| - | [[Category: Christopher | + | [[Category: Aves SJ]] |
| - | [[Category: Congreve | + | [[Category: Bennett KA]] |
| - | [[Category: Dore | + | [[Category: Christopher JA]] |
| - | [[Category: Errey | + | [[Category: Congreve M]] |
| - | [[Category: Jazayeri | + | [[Category: Dore AS]] |
| - | [[Category: Marshall | + | [[Category: Errey JC]] |
| - | [[Category: Okrasa | + | [[Category: Jazayeri A]] |
| - | [[Category: Serrano-Vega | + | [[Category: Marshall FH]] |
| - | [[Category: Tehan | + | [[Category: Okrasa K]] |
| - | [[Category: Wiggin | + | [[Category: Serrano-Vega MJ]] |
| - | + | [[Category: Tehan BG]] | |
| - | + | [[Category: Wiggin GR]] | |
| - | + | ||
| - | + | ||
Current revision
Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator 3-chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile - (HTL14242)
| |||||||||||
Categories: Escherichia virus T4 | Homo sapiens | Large Structures | Aves SJ | Bennett KA | Christopher JA | Congreve M | Dore AS | Errey JC | Jazayeri A | Marshall FH | Okrasa K | Serrano-Vega MJ | Tehan BG | Wiggin GR
