5cw5
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of CfBRCC36-CfKIAA0157 complex (QSQ mutant)== | |
| - | + | <StructureSection load='5cw5' size='340' side='right'caption='[[5cw5]], [[Resolution|resolution]] 2.74Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5cw5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Camponotus_floridanus Camponotus floridanus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CW5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CW5 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.736Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cw5 OCA], [https://pdbe.org/5cw5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cw5 RCSB], [https://www.ebi.ac.uk/pdbsum/5cw5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cw5 ProSAT]</span></td></tr> |
| - | [[Category: Zeqiraj | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BRCC3_CAMFO BRCC3_CAMFO] Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains, leaving the last ubiquitin chain attached to its substrates. Catalytic subunit of the BRISC complex; does not have activity by itself, but needs to be associated into a heterotetramer with ABRAXAS2 for minimal in vitro activity (PubMed:26344097). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating spindle assembly factors (By similarity).[UniProtKB:Q15018][UniProtKB:Q3TCJ1]<ref>PMID:26344097</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Camponotus floridanus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Zeqiraj E]] | ||
Current revision
Structure of CfBRCC36-CfKIAA0157 complex (QSQ mutant)
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