This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4rag

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:14, 8 November 2023) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
 +
==CRYSTAL STRUCTURE of PPC2A-D38K==
==CRYSTAL STRUCTURE of PPC2A-D38K==
-
<StructureSection load='4rag' size='340' side='right' caption='[[4rag]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
+
<StructureSection load='4rag' size='340' side='right'caption='[[4rag]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4rag]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RAG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RAG FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4rag]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RAG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RAG FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ra2|4ra2]], [[4raf|4raf]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rag FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rag OCA], [https://pdbe.org/4rag PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rag RCSB], [https://www.ebi.ac.uk/pdbsum/4rag PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rag ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rag FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rag OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rag RCSB], [http://www.ebi.ac.uk/pdbsum/4rag PDBsum]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/PPM1A_HUMAN PPM1A_HUMAN]] Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling.<ref>PMID:16751101</ref>
+
[https://www.uniprot.org/uniprot/PPM1A_HUMAN PPM1A_HUMAN] Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling.<ref>PMID:16751101</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 18: Line 18:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 4rag" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Protein phosphatase 3D structures|Protein phosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Phosphoprotein phosphatase]]
+
[[Category: Homo sapiens]]
-
[[Category: Liu, H D]]
+
[[Category: Large Structures]]
-
[[Category: Meng, F G]]
+
[[Category: Liu HD]]
-
[[Category: Pan, C]]
+
[[Category: Meng FG]]
-
[[Category: Sun, J P]]
+
[[Category: Pan C]]
-
[[Category: Tang, J Y]]
+
[[Category: Sun JP]]
-
[[Category: Wang, H A]]
+
[[Category: Tang JY]]
-
[[Category: Wang, W B]]
+
[[Category: Wang HA]]
-
[[Category: Xiao, P]]
+
[[Category: Wang WB]]
-
[[Category: Xu, Y F]]
+
[[Category: Xiao P]]
-
[[Category: Yu, X]]
+
[[Category: Xu YF]]
-
[[Category: Metal binding protein]]
+
[[Category: Yu X]]
-
[[Category: Phosphatation]]
+
-
[[Category: Pp2c family]]
+
-
[[Category: Serine/threonine phosphatase]]
+

Current revision

CRYSTAL STRUCTURE of PPC2A-D38K

PDB ID 4rag

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4rag"
Personal tools