1fnn

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[[Image:1fnn.gif|left|200px]]
 
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{{Structure
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==CRYSTAL STRUCTURE OF CDC6P FROM PYROBACULUM AEROPHILUM==
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|PDB= 1fnn |SIZE=350|CAPTION= <scene name='initialview01'>1fnn</scene>, resolution 2.0&Aring;
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<StructureSection load='1fnn' size='340' side='right'caption='[[1fnn]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>
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<table><tr><td colspan='2'>[[1fnn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrobaculum_aerophilum Pyrobaculum aerophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FNN FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fnn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnn OCA], [https://pdbe.org/1fnn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fnn RCSB], [https://www.ebi.ac.uk/pdbsum/1fnn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fnn ProSAT]</span></td></tr>
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</table>
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'''CRYSTAL STRUCTURE OF CDC6P FROM PYROBACULUM AEROPHILUM'''
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== Function ==
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[https://www.uniprot.org/uniprot/Q8ZYK1_PYRAE Q8ZYK1_PYRAE] Involved in regulation of DNA replication (By similarity).[HAMAP-Rule:MF_01407]
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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Cdc6/Cdc18 is a conserved and essential component of prereplication complexes. The 2.0 A crystal structure of an archaeal Cdc6 ortholog, in conjunction with a mutational analysis of the homologous Cdc18 protein from Schizosaccharomyces pombe, reveals novel aspects of Cdc6/Cdc18 function. Two domains of Cdc6 form an AAA+-type nucleotide binding fold that is observed bound to Mg.ADP. A third domain adopts a winged-helix fold similar to known DNA binding modules. Sequence comparisons show that the winged-helix domain is conserved in Orc1, and mutagenesis data demonstrate that this region of Cdc6/Cdc18 is required for function in vivo. Additional mutational analyses suggest that nucleotide binding and/or hydrolysis by Cdc6/Cdc18 is required not only for progression through S phase, but also for maintenance of checkpoint control during S phase.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fn/1fnn_consurf.spt"</scriptWhenChecked>
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1FNN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrobaculum_aerophilum Pyrobaculum aerophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNN OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Structure and function of Cdc6/Cdc18: implications for origin recognition and checkpoint control., Liu J, Smith CL, DeRyckere D, DeAngelis K, Martin GS, Berger JM, Mol Cell. 2000 Sep;6(3):637-48. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11030343 11030343]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fnn ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Pyrobaculum aerophilum]]
[[Category: Pyrobaculum aerophilum]]
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[[Category: Single protein]]
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[[Category: Berger JM]]
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[[Category: Berger, J M.]]
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[[Category: DeAngelis K]]
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[[Category: DeAngelis, K.]]
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[[Category: DeRyckere D]]
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[[Category: DeRyckere, D.]]
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[[Category: Liu J]]
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[[Category: Liu, J.]]
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[[Category: Martin GS]]
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[[Category: Martin, G S.]]
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[[Category: Smith CL]]
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[[Category: Smith, C L.]]
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[[Category: ADP]]
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[[Category: MG]]
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[[Category: aaa protein]]
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[[Category: cdc18]]
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[[Category: cdc6]]
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[[Category: cell cycle control factor]]
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[[Category: dna replication initation factor]]
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[[Category: orc1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 11:48:43 2008''
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Current revision

CRYSTAL STRUCTURE OF CDC6P FROM PYROBACULUM AEROPHILUM

PDB ID 1fnn

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