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4trw

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==Structure of BACE1 complex with a syn-HEA-type inhibitor==
==Structure of BACE1 complex with a syn-HEA-type inhibitor==
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<StructureSection load='4trw' size='340' side='right' caption='[[4trw]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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<StructureSection load='4trw' size='340' side='right'caption='[[4trw]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4trw]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TRW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TRW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4trw]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TRW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TRW FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LHE:N-[(2R,3S)-3-AMINO-2-HYDROXY-5-METHYLHEXYL]-L-NORVALINE'>LHE</scene>, <scene name='pdbligand=TIH:BETA(2-THIENYL)ALANINE'>TIH</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4trz|4trz]], [[4try|4try]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LHE:N-[(2R,3S)-3-AMINO-2-HYDROXY-5-METHYLHEXYL]-L-NORVALINE'>LHE</scene>, <scene name='pdbligand=TIH:BETA(2-THIENYL)ALANINE'>TIH</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4trw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4trw OCA], [https://pdbe.org/4trw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4trw RCSB], [https://www.ebi.ac.uk/pdbsum/4trw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4trw ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4trw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4trw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4trw RCSB], [http://www.ebi.ac.uk/pdbsum/4trw PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
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[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4trw" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Beta secretase 3D structures|Beta secretase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Memapsin 2]]
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[[Category: Homo sapiens]]
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[[Category: Akaji, K]]
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[[Category: Large Structures]]
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[[Category: Akiyama, T]]
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[[Category: Synthetic construct]]
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[[Category: Nakagawa, A]]
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[[Category: Akaji K]]
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[[Category: Sanjho, A]]
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[[Category: Akiyama T]]
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[[Category: Teruya, K]]
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[[Category: Nakagawa A]]
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[[Category: Yamashita, E]]
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[[Category: Sanjho A]]
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[[Category: Designed inhibitor]]
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[[Category: Teruya K]]
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[[Category: Hydrase proteinase converting]]
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[[Category: Yamashita E]]
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[[Category: Hydrase-inhibitor complex]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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Current revision

Structure of BACE1 complex with a syn-HEA-type inhibitor

PDB ID 4trw

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