5awj

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'''Unreleased structure'''
 
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The entry 5awj is ON HOLD until Paper Publication
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==Crystal structure of VDR-LBD/partial agonist complex: 22S-hexyl analogue==
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<StructureSection load='5awj' size='340' side='right'caption='[[5awj]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5awj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AWJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AWJ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YSL:(1R,3R)-5-[(2E)-2-[(1R,3AS,7AR)-1-[(2R,3S)-3-(2-HYDROXYETHYL)NONAN-2-YL]-7A-METHYL-2,3,3A,5,6,7-HEXAHYDRO-1H-INDEN-4-YLIDENE]ETHYLIDENE]-2-METHYLIDENE-CYCLOHEXANE-1,3-DIOL'>YSL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5awj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5awj OCA], [https://pdbe.org/5awj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5awj RCSB], [https://www.ebi.ac.uk/pdbsum/5awj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5awj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VDR_RAT VDR_RAT] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref>
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Authors: Anami, Y., Itoh, T., Inaba, Y., Nakabayashi, M., Ikura, T., Ito, N., Yamamoto, K.
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==See Also==
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*[[Vitamin D receptor 3D structures|Vitamin D receptor 3D structures]]
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Description: Crystal structure of VDR-LBD/partial agonist complex: 22S-hexyl analogue
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Nakabayashi, M]]
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__TOC__
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[[Category: Inaba, Y]]
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</StructureSection>
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[[Category: Yamamoto, K]]
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[[Category: Homo sapiens]]
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[[Category: Anami, Y]]
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[[Category: Large Structures]]
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[[Category: Ito, N]]
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[[Category: Rattus norvegicus]]
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[[Category: Itoh, T]]
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[[Category: Anami Y]]
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[[Category: Ikura, T]]
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[[Category: Ikura T]]
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[[Category: Inaba Y]]
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[[Category: Ito N]]
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[[Category: Itoh T]]
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[[Category: Nakabayashi M]]
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[[Category: Yamamoto K]]

Current revision

Crystal structure of VDR-LBD/partial agonist complex: 22S-hexyl analogue

PDB ID 5awj

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