5dc3
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Complex of yeast 80S ribosome with non-modified eIF5A== | |
| + | <StructureSection load='5dc3' size='340' side='right'caption='[[5dc3]], [[Resolution|resolution]] 3.25Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5dc3]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DC3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DC3 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.25Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dc3 OCA], [https://pdbe.org/5dc3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dc3 RCSB], [https://www.ebi.ac.uk/pdbsum/5dc3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dc3 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RSSA1_YEAST RSSA1_YEAST] Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.<ref>PMID:9973221</ref> <ref>PMID:14627813</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Eukaryotic translation initiation factor eIF5A promotes protein synthesis by resolving polyproline-induced ribosomal stalling. Here we report a 3.25A-resolution crystal structure of eIF5A bound to the yeast 80S ribosome. The structure reveals a previously unseen conformation of an eIF5A-ribosome complex and highlights a possible functional link between conformational changes of the ribosome during protein synthesis and the eIF5A-ribosome association. | ||
| - | + | Crystal structure of hypusine-containing translation factor eIF5A bound to a rotated eukaryotic ribosome.,Melnikov S, Mailliot J, Shin BS, Rigger L, Yusupova G, Micura R, Dever TE, Yusupov M J Mol Biol. 2016 May 16. pii: S0022-2836(16)30154-1. doi:, 10.1016/j.jmb.2016.05.011. PMID:27196944<ref>PMID:27196944</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Mailliot | + | <div class="pdbe-citations 5dc3" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | |
| - | [[Category: Micura | + | ==See Also== |
| - | [[Category: | + | *[[Ribosome 3D structures|Ribosome 3D structures]] |
| - | [[Category: Shin | + | *[[3D sructureseceptor for activated protein kinase C 1|3D sructureseceptor for activated protein kinase C 1]] |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Saccharomyces cerevisiae S288C]] | ||
| + | [[Category: Dever TE]] | ||
| + | [[Category: Mailliot J]] | ||
| + | [[Category: Melnikov S]] | ||
| + | [[Category: Micura R]] | ||
| + | [[Category: Rigger L]] | ||
| + | [[Category: Shin B-S]] | ||
| + | [[Category: Yusupov M]] | ||
| + | [[Category: Yusupova G]] | ||
Current revision
Complex of yeast 80S ribosome with non-modified eIF5A
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