5awc
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human TLR8 in complex with MB-564== | |
| + | <StructureSection load='5awc' size='340' side='right'caption='[[5awc]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5awc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AWC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AWC FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=M4D:5-(4-AZANYLBUTYL)-3-PENTYL-QUINOLIN-2-AMINE'>M4D</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5awc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5awc OCA], [https://pdbe.org/5awc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5awc RCSB], [https://www.ebi.ac.uk/pdbsum/5awc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5awc ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TLR8_HUMAN TLR8_HUMAN] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:17932028</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Shimizu | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ohto U]] | ||
| + | [[Category: Shimizu T]] | ||
| + | [[Category: Tanji H]] | ||
Current revision
Crystal structure of human TLR8 in complex with MB-564
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