5dcz

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'''Unreleased structure'''
 
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The entry 5dcz is ON HOLD until Paper Publication
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==Tankyrase 2 complexed with a selective inhibitor==
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<StructureSection load='5dcz' size='340' side='right'caption='[[5dcz]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5dcz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DCZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DCZ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.23&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=59B:MORPHOLIN-4-YL[4-(TETRAZOLO[1,5-A]QUINOXALIN-4-YLAMINO)PHENYL]METHANONE'>59B</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dcz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dcz OCA], [https://pdbe.org/5dcz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dcz RCSB], [https://www.ebi.ac.uk/pdbsum/5dcz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dcz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>
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Authors: Shewchuk, L.M., Muelbaier, M.
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==See Also==
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*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]
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Description: Tankyrase 2 complexed with a selective inhibitor
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Muelbaier, M]]
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__TOC__
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[[Category: Shewchuk, L.M]]
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Muelbaier M]]
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[[Category: Shewchuk LM]]

Current revision

Tankyrase 2 complexed with a selective inhibitor

PDB ID 5dcz

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