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| - | == Lysozyme ==
| + | <StructureSection load='3wja' size='340' side='right' caption='The best structure for NADP-dependent malic enzyme shown: [[3wja]]' scene=''> |
| - | <StructureSection load='1swy' size='340' side='right' caption='Caption for this structure' scene=''> | + | Best example is PDB entry [[3wja]] and is shown in the viewer.<br> |
| - | Best example is 1swy<br> | + | ==Catalytic Activity == |
| - | Molecule Lysozyme, also known as Lysozyme, CP-7 lysin, Muramidase, Endolysin, 1,4-beta-N-acetylmuramidase, Lysis protein, CP-1 lysin, Lysozyme murein hydrolase, Protein gp17, Transglycosylase, Hevamine-A, Chitinase and L-alanyl-D-glutamate peptidase.
| + | Oxaloacetate = pyruvate + CO(2).Data source: Uniprot [http://www.uniprot.org/uniprot/P48163 P48163]<br> |
| - | == Function == | + | Or the decarboxylation of malate to pyruvate<ref>PMID:8187880</ref>. |
| - | lysozyme activity<br>
| + | |
| - | catalytic activity<br>
| + | |
| - | hydrolase activity<br>
| + | |
| - | hydrolase activity, acting on glycosyl bonds<br>
| + | |
| - | carbon-oxygen lyase activity, acting on polysaccharides<br>
| + | |
| - | lyase activity<br>
| + | |
| - | chitinase activity<br>
| + | |
| - | hydrolase activity, hydrolyzing O-glycosyl compounds<br>
| + | |
| - | sequence-specific DNA binding<br>
| + | |
| | | | |
| - | == Disease == | |
| - | | |
| - | == Relevance == | |
| - | | |
| - | == Structural highlights == | |
| | == Biological process == | | == Biological process == |
| | Is involved in the following biological processes:<br> | | Is involved in the following biological processes:<br> |
| - | cell wall macromolecule catabolic process<br>
| + | malate metabolic process<br> |
| - | peptidoglycan catabolic process<br>
| + | oxidation-reduction process<br> |
| - | metabolic process<br>
| + | response to carbohydrate<br> |
| - | defense response to bacterium<br>
| + | response to hormone<br> |
| - | cytolysis<br>
| + | |
| - | viral release from host cell<br>
| + | |
| | carbohydrate metabolic process<br> | | carbohydrate metabolic process<br> |
| - | chitin catabolic process<br>
| + | protein tetramerization<br> |
| - | polysaccharide catabolic process<br>
| + | regulation of NADP metabolic process<br> |
| - | cytolysis by virus of host cell<br>
| + | NADP biosynthetic process<br> |
| - | cell wall organization<br>
| + | small molecule metabolic process<br> |
| | + | cellular lipid metabolic process<br> |
| | == In structures == | | == In structures == |
| - | Lysozyme is found in 595 PDB entries<br>
| + | NADP-dependent malic enzyme is found in 3 PDB entries<br> |
| - | Homo sapiens (2 PDB entries): <br> | + | *<b>Eukaryota</b> (3 PDB entries): <br> |
| - | [[ 4uis]] <div class="pdb-prints 4uis"></div> 4. 4 A resolution . [http://www.ebi.ac.uk/pdbe/entry/ emdb/ emd- 2974 emd- 2974] . Other macromolecules also in this entry: GAMMA-SECRETASE, Nicastrin, Presenilin-1 NTF subunit, GAMMA-SECRETASE.<br> | + | **<b>Homo sapiens</b> (2 PDB entries): <br> |
| - | Enterobacteria phage P22 (2 PDB entries): <br>
| + | ***[[ 3wja]] <div class="pdb-prints 3wja"></div> |
| - | [[2anv]] <div class="pdb-prints 2anv"></div> 1.04 A resolution. <br>
| + | ***Title: The crystal structure of human cytosolic NADP(+)-dependent malic enzyme in apo form |
| - | Enterobacteria phage P21 (2 PDB entries): <br>
| + | ***2.548 A resolution |
| - | [[ 3hdf]] <div class="pdb-prints 3hdf"></div> 1. 7 A resolution . <br> | + | ***[http://www.ebi.ac.uk/pdbe/entry/search/index?organism_scientific_name:%22Homo%20sapiens%22&all_molecule_names:%22NADP-dependent%20malic%20enzyme%22&!chimera:y Search the PDB for NADP-dependent malic enzyme from Homo sapiens] |
| - | Hevea brasiliensis (2 PDB entries): <br>
| + | **<b>Columba livia</b> (1 PDB entries): <br> |
| - | [[1kqy]] <div class="pdb-prints 1kqy"></div> 1.92 A resolution. <br>
| + | ***[[ 1gq2]] <div class="pdb-prints 1gq2"></div> |
| - | Escherichia phage T5 (2 PDB entries): <br>
| + | ***Title: MALIC ENZYME FROM PIGEON LIVER |
| - | [[2mxz]] <div class="pdb-prints 2mxz"></div> N/A A resolution. <br>
| + | ***2.5 A resolution |
| - | Streptococcus phage CP-7 (2 PDB entries): <br>
| + | == Alternative names for NADP-dependent malic enzyme == |
| - | [[4cvd]] <div class="pdb-prints 4cvd"></div> 1.666 A resolution. <br> | + | Molecule '''NADP-dependent malic enzyme''', also known as '''NADP-ME''', '''NADP-dependent malic enzyme''' and '''Malic enzyme 1'''. |
| - | Antheraea mylitta (2 PDB entries): <br>
| + | |
| - | [[1iiz]] <div class="pdb-prints 1iiz"></div> 2.4 A resolution. <br> | + | == 3D Structures of NADP-dependent malic enzyme == |
| - | Mus musculus (2 PDB entries): <br>
| + | |
| - | [[1iak]] <div class="pdb-prints 1iak"></div> 1.9 A resolution. Other macromolecules also in this entry: H-2 class II histocompatibility antigen, A-K beta chain, H-2 class II histocompatibility antigen, A-K alpha chain.<br> | + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} |
| - | Bombyx mori (2 PDB entries): <br>
| + | |
| - | [[1gd6]] <div class="pdb-prints 1gd6"></div> 2.5 A resolution. <br> | + | |
| - | Streptococcus phage Cp-1 (2 PDB entries): <br>
| + | [[3wja]], [[2aw5]] – hME - human<br /> |
| - | [[2j8g]] <div class="pdb-prints 2j8g"></div> 1.69 A resolution. <br> | + | [[7x11]], [[7x12]] – hME1 + NADP<br /> |
| - | Enterobacteria phage T4 (2 PDB entries): <br>
| + | [[8e76]], [[8eyn]] – hME3<br /> |
| - | [[1swy]] <div class="pdb-prints 1swy"></div> 1.06 A resolution. <br> | + | [[8e78]], [[8e8o]], [[8eyo]] – hME3 + NADP<br /> |
| - | Enterobacteria phage P1 (2 PDB entries): <br>
| + | [[1gq2]] – ME + NADP - pigeon<br /> |
| - | [[1xju]] <div class="pdb-prints 1xju"></div> 1.07 A resolution. <br> | + | [[5ou5]] – ME - maize<br /> |
| - | Enterobacteria phage lambda (2 PDB entries): <br>
| + | |
| - | [[1am7]] <div class="pdb-prints 1am7"></div> 2.3 A resolution. <br> | + | == References == |
| - | Meretrix lusoria (2 PDB entries): <br>
| + | <references/> |
| - | [[4pj2]] <div class="pdb-prints 4pj2"></div> 1.24 A resolution. Other macromolecules also in this entry: Putative exported protein, Putative exported protein.<br> | + | [[Category:Topic Page]][[Category:PDBe]] |
| - | Ruditapes philippinarum (2 PDB entries): <br>
| + | |
| - | [[2dqa]] <div class="pdb-prints 2dqa"></div> 1.6 A resolution. <br> | + | |
| - | Escherichia coli (2 PDB entries): <br>
| + | |
| - | [[2qb0]] <div class="pdb-prints 2qb0"></div> 2.56 A resolution. Other macromolecules also in this entry: Transcription factor ETV6, Transcription factor ETV6.<br> | + | |
