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2fh7

From Proteopedia

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==Crystal structure of the phosphatase domains of human PTP SIGMA==
==Crystal structure of the phosphatase domains of human PTP SIGMA==
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<StructureSection load='2fh7' size='340' side='right' caption='[[2fh7]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='2fh7' size='340' side='right'caption='[[2fh7]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2fh7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FH7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FH7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2fh7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FH7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FH7 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTPRS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fh7 OCA], [https://pdbe.org/2fh7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fh7 RCSB], [https://www.ebi.ac.uk/pdbsum/2fh7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fh7 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2fh7 TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fh7 OCA], [http://pdbe.org/2fh7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fh7 RCSB], [http://www.ebi.ac.uk/pdbsum/2fh7 PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/2fh7 TOPSAN]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PTPRS_HUMAN PTPRS_HUMAN]] Interacts with LAR-interacting protein LIP.1.
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[https://www.uniprot.org/uniprot/PTPRS_HUMAN PTPRS_HUMAN] Interacts with LAR-interacting protein LIP.1.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fh/2fh7_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fh/2fh7_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fh7 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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==See Also==
==See Also==
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*[[Tyrosine phosphatase|Tyrosine phosphatase]]
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Large Structures]]
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[[Category: Almo, S C]]
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[[Category: Almo SC]]
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[[Category: Alvarado, J]]
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[[Category: Alvarado J]]
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[[Category: Atwell, S]]
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[[Category: Atwell S]]
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[[Category: Bain, K T]]
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[[Category: Bain KT]]
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[[Category: Burley, S K]]
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[[Category: Burley SK]]
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[[Category: Freeman, J C]]
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[[Category: Freeman JC]]
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[[Category: Kearins, M C]]
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[[Category: Kearins MC]]
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[[Category: Koss, J]]
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[[Category: Koss J]]
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[[Category: Maletic, M]]
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[[Category: Maletic M]]
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[[Category: Structural genomic]]
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[[Category: Ozyurt S]]
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[[Category: Ozyurt, S]]
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[[Category: Powell A]]
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[[Category: Powell, A]]
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[[Category: Rooney I]]
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[[Category: Rooney, I]]
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[[Category: Russell M]]
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[[Category: Russell, M]]
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[[Category: Sauder JM]]
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[[Category: Sauder, J M]]
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[[Category: Smith D]]
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[[Category: Smith, D]]
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[[Category: Thompson DA]]
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[[Category: Thompson, D A]]
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[[Category: Udupi R]]
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[[Category: Udupi, R]]
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[[Category: Wasserman SR]]
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[[Category: Wasserman, S R]]
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[[Category: Dual domain phosphatase]]
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[[Category: Hydrolase]]
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[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Receptor protein tyrosine phosphatase]]
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Current revision

Crystal structure of the phosphatase domains of human PTP SIGMA

PDB ID 2fh7

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