1sac
From Proteopedia
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==THE STRUCTURE OF PENTAMERIC HUMAN SERUM AMYLOID P COMPONENT== | ==THE STRUCTURE OF PENTAMERIC HUMAN SERUM AMYLOID P COMPONENT== | ||
| - | <StructureSection load='1sac' size='340' side='right' caption='[[1sac]], [[Resolution|resolution]] 2.00Å' scene=''> | + | <StructureSection load='1sac' size='340' side='right'caption='[[1sac]], [[Resolution|resolution]] 2.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1sac]] is a 5 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1sac]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SAC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SAC FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sac OCA], [https://pdbe.org/1sac PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sac RCSB], [https://www.ebi.ac.uk/pdbsum/1sac PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sac ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/SAMP_HUMAN SAMP_HUMAN] Note=SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits. |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/SAMP_HUMAN SAMP_HUMAN] Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sa/1sac_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sa/1sac_consurf.spt"</scriptWhenChecked> |
| - | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> |
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sac ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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</div> | </div> | ||
<div class="pdbe-citations 1sac" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 1sac" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Serum amyloid P-component|Serum amyloid P-component]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Blundell | + | [[Category: Large Structures]] |
| - | [[Category: Emsley | + | [[Category: Blundell TL]] |
| - | [[Category: | + | [[Category: Emsley J]] |
| - | [[Category: Oliva | + | [[Category: O'Hara BP]] |
| - | [[Category: Pepys | + | [[Category: Oliva G]] |
| - | [[Category: Srinivasan | + | [[Category: Pepys MB]] |
| - | [[Category: Tickle | + | [[Category: Srinivasan N]] |
| - | [[Category: White | + | [[Category: Tickle IJ]] |
| - | [[Category: Wood | + | [[Category: White HE]] |
| - | + | [[Category: Wood SP]] | |
Current revision
THE STRUCTURE OF PENTAMERIC HUMAN SERUM AMYLOID P COMPONENT
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Categories: Homo sapiens | Large Structures | Blundell TL | Emsley J | O'Hara BP | Oliva G | Pepys MB | Srinivasan N | Tickle IJ | White HE | Wood SP
