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1moz

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[[Image:1moz.gif|left|200px]]
 
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{{Structure
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==ADP-ribosylation factor-like 1 (ARL1) from Saccharomyces cerevisiae==
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|PDB= 1moz |SIZE=350|CAPTION= <scene name='initialview01'>1moz</scene>, resolution 3.17&Aring;
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<StructureSection load='1moz' size='340' side='right'caption='[[1moz]], [[Resolution|resolution]] 3.17&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>
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<table><tr><td colspan='2'>[[1moz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MOZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MOZ FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.17&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1moz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1moz OCA], [https://pdbe.org/1moz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1moz RCSB], [https://www.ebi.ac.uk/pdbsum/1moz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1moz ProSAT]</span></td></tr>
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</table>
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'''ADP-ribosylation factor-like 1 (ARL1) from Saccharomyces cerevisiae'''
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== Function ==
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[https://www.uniprot.org/uniprot/ARL1_YEAST ARL1_YEAST] Recruits golgins such as IMH1 to the Golgi. Can bind and hydrolyze GTP. May be involved in trafficking events within the endosomal system.<ref>PMID:12052896</ref> <ref>PMID:12620188</ref> <ref>PMID:12620189</ref>
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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Structures were determined by x-ray crystallography for two members of the ADP-ribosylation factor (ARF) family of regulatory GTPases, yeast ARF1 and ARL1, and were compared with previously determined structures of human ARF1 and ARF6. These analyses revealed an overall conserved fold but differences in primary sequence and length, particularly in an N-terminal loop, lead to differences in nucleotide and divalent metal binding. Packing of hydrophobic residues is central to the interplay between the N-terminal alpha-helix, switch I, and the interswitch region, which along with differences in surface electrostatics provide explanations for the different biophysical and biochemical properties of ARF and ARF-like proteins.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mo/1moz_consurf.spt"</scriptWhenChecked>
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1MOZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MOZ OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Structures of yeast ARF2 and ARL1: distinct roles for the N terminus in the structure and function of ARF family GTPases., Amor JC, Horton JR, Zhu X, Wang Y, Sullards C, Ringe D, Cheng X, Kahn RA, J Biol Chem. 2001 Nov 9;276(45):42477-84. Epub 2001 Sep 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11535602 11535602]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1moz ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Amor JC]]
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[[Category: Amor, J C.]]
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[[Category: Cheng X]]
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[[Category: Cheng, X.]]
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[[Category: Horton JR]]
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[[Category: Horton, J R.]]
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[[Category: Kahn RA]]
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[[Category: Kahn, R A.]]
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[[Category: Ringe D]]
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[[Category: Ringe, D.]]
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[[Category: Sullards C]]
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[[Category: Sullards, C.]]
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[[Category: Wang Y]]
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[[Category: Wang, Y.]]
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[[Category: Zhu X]]
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[[Category: Zhu, X.]]
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[[Category: GDP]]
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[[Category: gtp-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 12:47:28 2008''
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Current revision

ADP-ribosylation factor-like 1 (ARL1) from Saccharomyces cerevisiae

PDB ID 1moz

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