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2jxx
From Proteopedia
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==NMR solution structure of Ubiquitin-like domain of NFATC2IP. Northeast Structural Genomics Consortium target HR5627== | ==NMR solution structure of Ubiquitin-like domain of NFATC2IP. Northeast Structural Genomics Consortium target HR5627== | ||
| - | <StructureSection load='2jxx' size='340' side='right' caption='[[2jxx | + | <StructureSection load='2jxx' size='340' side='right'caption='[[2jxx]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2jxx]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2jxx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JXX FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxx OCA], [https://pdbe.org/2jxx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jxx RCSB], [https://www.ebi.ac.uk/pdbsum/2jxx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jxx ProSAT], [https://www.topsan.org/Proteins/NESGC/2jxx TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/NF2IP_HUMAN NF2IP_HUMAN] In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/2jxx_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/2jxx_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jxx ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Arrowsmith | + | [[Category: Large Structures]] |
| - | [[Category: Butler | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Dhe-Paganon | + | [[Category: Butler C]] |
| - | [[Category: Doherty | + | [[Category: Dhe-Paganon S]] |
| - | [[Category: Edwards | + | [[Category: Doherty RS]] |
| - | [[Category: Fares | + | [[Category: Edwards AM]] |
| - | [[Category: Karra | + | [[Category: Fares C]] |
| - | [[Category: Lemak | + | [[Category: Karra M]] |
| - | + | [[Category: Lemak A]] | |
| - | [[Category: Srisailam | + | [[Category: Srisailam S]] |
| - | [[Category: Weigelt | + | [[Category: Weigelt J]] |
| - | [[Category: Yee | + | [[Category: Yee A]] |
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Current revision
NMR solution structure of Ubiquitin-like domain of NFATC2IP. Northeast Structural Genomics Consortium target HR5627
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Butler C | Dhe-Paganon S | Doherty RS | Edwards AM | Fares C | Karra M | Lemak A | Srisailam S | Weigelt J | Yee A
