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1nwz

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[[Image:1nwz.gif|left|200px]]
 
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{{Structure
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==PYP Ultra-high resolution structure of a Bacterial Photoreceptor==
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|PDB= 1nwz |SIZE=350|CAPTION= <scene name='initialview01'>1nwz</scene>, resolution 0.82&Aring;
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<StructureSection load='1nwz' size='340' side='right'caption='[[1nwz]], [[Resolution|resolution]] 0.82&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=HC4:4&#39;-HYDROXYCINNAMIC ACID'>HC4</scene>
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<table><tr><td colspan='2'>[[1nwz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Halorhodospira_halophila Halorhodospira halophila]. The March 2015 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Phototropin'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2015_3 10.2210/rcsb_pdb/mom_2015_3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NWZ FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.82&#8491;</td></tr>
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|GENE= PYP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1053 Halorhodospira halophila])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HC4:4-HYDROXYCINNAMIC+ACID'>HC4</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nwz OCA], [https://pdbe.org/1nwz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nwz RCSB], [https://www.ebi.ac.uk/pdbsum/1nwz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nwz ProSAT]</span></td></tr>
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</table>
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'''PYP ULTRA-HIGH RESOLUTION STRUCTURE OF A BACTERIAL PHOTORECEPTOR'''
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== Function ==
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[https://www.uniprot.org/uniprot/PYP_HALHA PYP_HALHA] Photoactive blue light protein. Probably functions as a photoreceptor for a negative phototaxis response.
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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Protein photoreceptors use small-molecule cofactors called chromophores to detect light. Only under the influence of the receptors' active sites do these chromophores adopt spectral and photochemical properties that suit the receptors' functional requirements. This protein-induced change in chromophore properties is called photochemical tuning and is a prime example for the general--but poorly understood--process of chemical tuning through which proteins shape the reactivity of their active-site groups. Here we report the 0.82-A resolution X-ray structure of the bacterial light receptor photoactive yellow protein (PYP). The unusually precise structure reveals deviations from expected molecular geometries and anisotropic atomic displacements in the PYP active site. Our analysis of these deviations points directly to the intramolecular forces and active-site dynamics that tune the properties of PYP's chromophore to absorb blue light, suppress fluorescence, and favor the required light-driven double-bond isomerization.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nw/1nwz_consurf.spt"</scriptWhenChecked>
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1NWZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Halorhodospira_halophila Halorhodospira halophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NWZ OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Anticipatory active-site motions and chromophore distortion prime photoreceptor PYP for light activation., Getzoff ED, Gutwin KN, Genick UK, Nat Struct Biol. 2003 Aug;10(8):663-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12872160 12872160]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nwz ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Halorhodospira halophila]]
[[Category: Halorhodospira halophila]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Genick, U K.]]
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[[Category: Phototropin]]
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[[Category: Getzoff, E D.]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Gutwin, K N.]]
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[[Category: Genick UK]]
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[[Category: HC4]]
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[[Category: Getzoff ED]]
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[[Category: domains fold]]
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[[Category: Gutwin KN]]
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[[Category: gaf]]
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[[Category: lov]]
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[[Category: pa]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 12:58:08 2008''
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Current revision

PYP Ultra-high resolution structure of a Bacterial Photoreceptor

PDB ID 1nwz

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