1xyw

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==elk prion protein==
==elk prion protein==
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<StructureSection load='1xyw' size='340' side='right' caption='[[1xyw]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='1xyw' size='340' side='right'caption='[[1xyw]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1xyw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/American_elk American elk]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XYW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XYW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1xyw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cervus_canadensis_nelsoni Cervus canadensis nelsoni]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XYW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XYW FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Prnp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9864 American elk])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xyw OCA], [http://pdbe.org/1xyw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xyw RCSB], [http://www.ebi.ac.uk/pdbsum/1xyw PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xyw OCA], [https://pdbe.org/1xyw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xyw RCSB], [https://www.ebi.ac.uk/pdbsum/1xyw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xyw ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/PRIO_CEREN PRIO_CEREN]] Note=PrP is found in high quantity in the brain of humans and animals infected with the degenerative neurological diseases kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
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[https://www.uniprot.org/uniprot/PRIO_CEREN PRIO_CEREN] Note=PrP is found in high quantity in the brain of humans and animals infected with the degenerative neurological diseases kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PRIO_CEREN PRIO_CEREN]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
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[https://www.uniprot.org/uniprot/PRIO_CEREN PRIO_CEREN] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xy/1xyw_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xy/1xyw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xyw ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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==See Also==
==See Also==
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*[[Prion|Prion]]
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*[[Prion 3D structures|Prion 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: American elk]]
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[[Category: Cervus canadensis nelsoni]]
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[[Category: Bonjour, S]]
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[[Category: Large Structures]]
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[[Category: Fiorito, F]]
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[[Category: Bonjour S]]
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[[Category: Gossert, A D]]
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[[Category: Fiorito F]]
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[[Category: Lysek, D A]]
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[[Category: Gossert AD]]
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[[Category: Wuthrich, K]]
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[[Category: Lysek DA]]
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[[Category: Cwd]]
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[[Category: Wuthrich K]]
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[[Category: Prion protein]]
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[[Category: Prp]]
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[[Category: Tse]]
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[[Category: Unknown function]]
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Current revision

elk prion protein

PDB ID 1xyw

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OCA

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