2h28

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==Crystal structure of YeeU from E. coli. Northeast Structural Genomics target ER304==
==Crystal structure of YeeU from E. coli. Northeast Structural Genomics target ER304==
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<StructureSection load='2h28' size='340' side='right' caption='[[2h28]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='2h28' size='340' side='right'caption='[[2h28]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2h28]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H28 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2H28 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2h28]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H28 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H28 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">yeeU ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h28 OCA], [https://pdbe.org/2h28 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h28 RCSB], [https://www.ebi.ac.uk/pdbsum/2h28 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h28 ProSAT], [https://www.topsan.org/Proteins/NESGC/2h28 TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h28 OCA], [http://pdbe.org/2h28 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2h28 RCSB], [http://www.ebi.ac.uk/pdbsum/2h28 PDBsum], [http://www.topsan.org/Proteins/NESGC/2h28 TOPSAN]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CBEA_ECOLI CBEA_ECOLI]] Antitoxin component of a type IV toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of its cognate toxin CbtA (YeeV). It does not bind to the toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles; it is probably retained in the MreB and FtsZ filament bundles. The mechanism has been proposed to require intergenic DNA, in cis, between the cbeA (yeeU) and cbta (yeeV) genes (PubMed:14594833). The intergenic region was not found to be necessary in another study (PubMed:22515815). Also counteracts the morphological defects caused by overexpression of SulA and DicB on cell shape.<ref>PMID:14594833</ref> <ref>PMID:22515815</ref>
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[https://www.uniprot.org/uniprot/CBEA_ECOLI CBEA_ECOLI] Antitoxin component of a type IV toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of its cognate toxin CbtA (YeeV). It does not bind to the toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles; it is probably retained in the MreB and FtsZ filament bundles. The mechanism has been proposed to require intergenic DNA, in cis, between the cbeA (yeeU) and cbta (yeeV) genes (PubMed:14594833). The intergenic region was not found to be necessary in another study (PubMed:22515815). Also counteracts the morphological defects caused by overexpression of SulA and DicB on cell shape.<ref>PMID:14594833</ref> <ref>PMID:22515815</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h2/2h28_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h2/2h28_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h28 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: Acton, T B]]
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[[Category: Large Structures]]
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[[Category: Arbing, M]]
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[[Category: Acton TB]]
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[[Category: Benach, J]]
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[[Category: Arbing M]]
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[[Category: Chen, C X]]
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[[Category: Benach J]]
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[[Category: Cunningham, K]]
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[[Category: Chen CX]]
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[[Category: Hunt, J F]]
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[[Category: Cunningham K]]
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[[Category: Jiang, M]]
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[[Category: Hunt JF]]
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[[Category: Karpowich, N K]]
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[[Category: Jiang M]]
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[[Category: Ma, L C]]
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[[Category: Karpowich NK]]
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[[Category: Montelione, G T]]
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[[Category: Ma L-C]]
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[[Category: Structural genomic]]
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[[Category: Montelione GT]]
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[[Category: Su, M]]
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[[Category: Su M]]
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[[Category: Tong, L]]
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[[Category: Tong L]]
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[[Category: Xiao, R]]
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[[Category: Xiao R]]
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[[Category: E. coli]]
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[[Category: Er304]]
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[[Category: Nesg]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Unknown function]]
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Current revision

Crystal structure of YeeU from E. coli. Northeast Structural Genomics target ER304

PDB ID 2h28

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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