2a2j

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==Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from Mycobacterium tuberculosis==
==Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from Mycobacterium tuberculosis==
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<StructureSection load='2a2j' size='340' side='right' caption='[[2a2j]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='2a2j' size='340' side='right'caption='[[2a2j]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2a2j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A2J FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2a2j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A2J FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyridoxal_5'-phosphate_synthase Pyridoxal 5'-phosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.5 1.4.3.5] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a2j OCA], [http://pdbe.org/2a2j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2a2j RCSB], [http://www.ebi.ac.uk/pdbsum/2a2j PDBsum], [http://www.topsan.org/Proteins/TBSGC/2a2j TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a2j OCA], [https://pdbe.org/2a2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a2j RCSB], [https://www.ebi.ac.uk/pdbsum/2a2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a2j ProSAT], [https://www.topsan.org/Proteins/TBSGC/2a2j TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PDXH_MYCTU PDXH_MYCTU]] Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity).[HAMAP-Rule:MF_01629]
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[https://www.uniprot.org/uniprot/PDXH_MYCTU PDXH_MYCTU] Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity).[HAMAP-Rule:MF_01629]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a2/2a2j_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a2/2a2j_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a2j ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Pyridoxal 5'-phosphate synthase]]
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[[Category: Large Structures]]
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[[Category: Hung, L W]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Kim, C Y]]
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[[Category: Hung L-W]]
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[[Category: Kim, S I]]
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[[Category: Kim C-Y]]
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[[Category: Lekin, T P]]
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[[Category: Kim S-I]]
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[[Category: Pedelacq, J D]]
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[[Category: Lekin TP]]
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[[Category: Rho, B S]]
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[[Category: Pedelacq J-D]]
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[[Category: Rupp, B]]
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[[Category: Rho B-S]]
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[[Category: Segelke, B W]]
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[[Category: Rupp B]]
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[[Category: Terwilliger, T C]]
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[[Category: Segelke BW]]
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[[Category: Waldo, G S]]
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[[Category: Terwilliger TC]]
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[[Category: XMTB, Mycobacterium Tuberculosis Structural Proteomics Project]]
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[[Category: Waldo GS]]
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[[Category: Beta barrel]]
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[[Category: Mycobacterium tuberculosis structural proteomics project]]
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[[Category: Oxidoreductase]]
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[[Category: Structural genomic]]
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[[Category: Xmtb]]
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Current revision

Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from Mycobacterium tuberculosis

PDB ID 2a2j

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