2g0n
From Proteopedia
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==The Crystal Structure of the Human RAC3 in complex with GDP and Chloride== | ==The Crystal Structure of the Human RAC3 in complex with GDP and Chloride== | ||
| - | <StructureSection load='2g0n' size='340' side='right' caption='[[2g0n]], [[Resolution|resolution]] 1.90Å' scene=''> | + | <StructureSection load='2g0n' size='340' side='right'caption='[[2g0n]], [[Resolution|resolution]] 1.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2g0n]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2g0n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G0N FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | < | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g0n OCA], [https://pdbe.org/2g0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g0n RCSB], [https://www.ebi.ac.uk/pdbsum/2g0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g0n ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/RAC3_HUMAN RAC3_HUMAN] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles.<ref>PMID:11956649</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g0/2g0n_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g0/2g0n_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g0n ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
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| + | ==See Also== | ||
| + | *[[Rac 3D structures|Rac 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Arrowsmith | + | [[Category: Large Structures]] |
| - | [[Category: Bunkoczi | + | [[Category: Arrowsmith C]] |
| - | [[Category: Burgess | + | [[Category: Bunkoczi G]] |
| - | [[Category: Colebrook | + | [[Category: Burgess N]] |
| - | + | [[Category: Colebrook S]] | |
| - | [[Category: Doyle | + | [[Category: Doyle D]] |
| - | [[Category: Edwards | + | [[Category: Edwards A]] |
| - | [[Category: Elkins | + | [[Category: Elkins J]] |
| - | [[Category: Fedorov | + | [[Category: Fedorov O]] |
| - | [[Category: Gileadi | + | [[Category: Gileadi C]] |
| - | [[Category: Gileadi | + | [[Category: Gileadi O]] |
| - | + | [[Category: Sundstrom M]] | |
| - | [[Category: Sundstrom | + | [[Category: Ugochukwu E]] |
| - | [[Category: Ugochukwu | + | [[Category: Weigelt J]] |
| - | [[Category: Weigelt | + | [[Category: Yang X]] |
| - | [[Category: Yang | + | [[Category: Zao Y]] |
| - | [[Category: Zao | + | [[Category: Von Delft F]] |
| - | [[Category: | + | |
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Current revision
The Crystal Structure of the Human RAC3 in complex with GDP and Chloride
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Categories: Homo sapiens | Large Structures | Arrowsmith C | Bunkoczi G | Burgess N | Colebrook S | Doyle D | Edwards A | Elkins J | Fedorov O | Gileadi C | Gileadi O | Sundstrom M | Ugochukwu E | Weigelt J | Yang X | Zao Y | Von Delft F
