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2c8a

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==STRUCTURE OF THE WILD-TYPE C3BOT1 EXOENZYME (NICOTINAMIDE-BOUND STATE, CRYSTAL FORM I)==
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<StructureSection load='2c8a' size='340' side='right' caption='[[2c8a]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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==Structure of the wild-type C3bot1 Exoenzyme (Nicotinamide-bound state, crystal form I)==
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<StructureSection load='2c8a' size='340' side='right'caption='[[2c8a]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2c8a]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_botulinus"_van_ermengem_1896 "bacillus botulinus" van ermengem 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C8A FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2c8a]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C8A FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCA:NICOTINAMIDE'>NCA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1g24|1g24]], [[1gze|1gze]], [[1gzf|1gzf]], [[1uzi|1uzi]], [[2a78|2a78]], [[2a9k|2a9k]], [[2bov|2bov]], [[2c89|2c89]], [[2c8b|2c8b]], [[2c8c|2c8c]], [[2c8d|2c8d]], [[2c8e|2c8e]], [[2c8f|2c8f]], [[2c8g|2c8g]], [[2c8h|2c8h]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NCA:NICOTINAMIDE'>NCA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c8a OCA], [http://pdbe.org/2c8a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c8a RCSB], [http://www.ebi.ac.uk/pdbsum/2c8a PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c8a OCA], [https://pdbe.org/2c8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c8a RCSB], [https://www.ebi.ac.uk/pdbsum/2c8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c8a ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ARC3_CBDP ARC3_CBDP]] ADP-ribosylates eukaryotic Rho and Rac proteins on an asparagine residue.
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[https://www.uniprot.org/uniprot/Q7M0L1_CLOBO Q7M0L1_CLOBO]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c8/2c8a_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c8/2c8a_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c8a ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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==See Also==
==See Also==
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*[[Exoenzyme|Exoenzyme]]
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*[[Exoenzyme 3D structures|Exoenzyme 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus botulinus van ermengem 1896]]
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[[Category: Clostridium botulinum]]
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[[Category: Boquet, P]]
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[[Category: Large Structures]]
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[[Category: Flatau, G]]
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[[Category: Boquet P]]
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[[Category: Menetrey, J]]
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[[Category: Flatau G]]
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[[Category: Menez, A]]
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[[Category: Menetrey J]]
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[[Category: Stura, E A]]
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[[Category: Menez A]]
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[[Category: Artt motif]]
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[[Category: Stura EA]]
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[[Category: Bacterial toxin]]
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[[Category: C3 exoenzyme]]
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[[Category: Glycosyltransferase]]
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[[Category: Transferase]]
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Current revision

Structure of the wild-type C3bot1 Exoenzyme (Nicotinamide-bound state, crystal form I)

PDB ID 2c8a

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