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1spq

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==Understanding protein lids: Structural analysis of active hinge mutants in triosephosphate isomerase==
==Understanding protein lids: Structural analysis of active hinge mutants in triosephosphate isomerase==
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<StructureSection load='1spq' size='340' side='right' caption='[[1spq]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
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<StructureSection load='1spq' size='340' side='right'caption='[[1spq]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1spq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SPQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SPQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1spq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SPQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SPQ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.16&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1sq7|1sq7]], [[1ssd|1ssd]], [[1ssg|1ssg]], [[1su5|1su5]], [[1sw0|1sw0]], [[1sw3|1sw3]], [[1sw7|1sw7]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TPI1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1spq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1spq OCA], [https://pdbe.org/1spq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1spq RCSB], [https://www.ebi.ac.uk/pdbsum/1spq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1spq ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1spq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1spq OCA], [http://pdbe.org/1spq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1spq RCSB], [http://www.ebi.ac.uk/pdbsum/1spq PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TPIS_CHICK TPIS_CHICK]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sp/1spq_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sp/1spq_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1spq ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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==See Also==
==See Also==
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*[[Triose Phosphate Isomerase|Triose Phosphate Isomerase]]
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*[[Triose phosphate isomerase 3D structures|Triose phosphate isomerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chick]]
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[[Category: Gallus gallus]]
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[[Category: Triose-phosphate isomerase]]
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[[Category: Large Structures]]
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[[Category: Haapalainen, A M]]
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[[Category: Haapalainen AM]]
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[[Category: Kursula, I]]
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[[Category: Kursula I]]
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[[Category: Norledge, B V]]
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[[Category: Norledge BV]]
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[[Category: Salin, M]]
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[[Category: Salin M]]
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[[Category: Sampson, N S]]
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[[Category: Sampson NS]]
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[[Category: Sun, J]]
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[[Category: Sun J]]
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[[Category: Wierenga, R K]]
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[[Category: Wierenga RK]]
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[[Category: Archae]]
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[[Category: Evolution]]
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[[Category: Flexible loop-6]]
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[[Category: Isomerase]]
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[[Category: N-hinge]]
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[[Category: Tim]]
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Current revision

Understanding protein lids: Structural analysis of active hinge mutants in triosephosphate isomerase

PDB ID 1spq

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