2j1l
From Proteopedia
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| - | == | + | |
| - | <StructureSection load='2j1l' size='340' side='right' caption='[[2j1l]], [[Resolution|resolution]] 2.50Å' scene=''> | + | ==Crystal Structure of Human Rho-related GTP-binding protein RhoD== |
| + | <StructureSection load='2j1l' size='340' side='right'caption='[[2j1l]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2j1l]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2j1l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J1L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J1L FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j1l OCA], [https://pdbe.org/2j1l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j1l RCSB], [https://www.ebi.ac.uk/pdbsum/2j1l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j1l ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RHOD_HUMAN RHOD_HUMAN] Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution.<ref>PMID:23087206</ref> <ref>PMID:23454120</ref> <ref>PMID:24102721</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j1/2j1l_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j1/2j1l_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j1l ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[GTP-binding protein|GTP-binding protein]] | + | *[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]] |
| + | *[[Rho GTPase 3D structures|Rho GTPase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith C]] |
| - | [[Category: Bray | + | [[Category: Bray J]] |
| - | + | [[Category: Doyle D]] | |
| - | [[Category: Doyle | + | [[Category: Edwards A]] |
| - | [[Category: Edwards | + | [[Category: Elkins J]] |
| - | [[Category: Elkins | + | [[Category: Gileadi C]] |
| - | [[Category: Gileadi | + | [[Category: Gorrec F]] |
| - | [[Category: Gorrec | + | [[Category: Johansson C]] |
| - | [[Category: Johansson | + | [[Category: Niesen FH]] |
| - | [[Category: Niesen | + | [[Category: Pike ACW]] |
| - | [[Category: Pike | + | [[Category: Schoch G]] |
| - | [[Category: Schoch | + | [[Category: Smee C]] |
| - | [[Category: Smee | + | [[Category: Sobott F]] |
| - | [[Category: Sobott | + | [[Category: Sundstrom M]] |
| - | [[Category: Sundstrom | + | [[Category: Turnbull AP]] |
| - | [[Category: Turnbull | + | [[Category: Watt S]] |
| - | [[Category: Watt | + | [[Category: Weigelt J]] |
| - | [[Category: Weigelt | + | [[Category: Von Delft F]] |
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Current revision
Crystal Structure of Human Rho-related GTP-binding protein RhoD
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Categories: Homo sapiens | Large Structures | Arrowsmith C | Bray J | Doyle D | Edwards A | Elkins J | Gileadi C | Gorrec F | Johansson C | Niesen FH | Pike ACW | Schoch G | Smee C | Sobott F | Sundstrom M | Turnbull AP | Watt S | Weigelt J | Von Delft F
