This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2lbv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:55, 14 June 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Siderocalin Q83 reveals a dual ligand binding mode==
==Siderocalin Q83 reveals a dual ligand binding mode==
-
<StructureSection load='2lbv' size='340' side='right' caption='[[2lbv]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+
<StructureSection load='2lbv' size='340' side='right'caption='[[2lbv]]' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2lbv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cotja Cotja]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LBV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LBV FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2lbv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Coturnix_japonica Coturnix japonica]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LBV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LBV FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACD:ARACHIDONIC+ACID'>ACD</scene>, <scene name='pdbligand=EB4:N,N,N-[(3S,7S,11S)-2,6,10-TRIOXO-1,5,9-TRIOXACYCLODODECANE-3,7,11-TRIYL]TRIS(2,3-DIHYDROXYBENZAMIDE)'>EB4</scene>, <scene name='pdbligand=GA:GALLIUM+(III)+ION'>GA</scene></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACD:ARACHIDONIC+ACID'>ACD</scene>, <scene name='pdbligand=EB4:N,N,N-[(3S,7S,11S)-2,6,10-TRIOXO-1,5,9-TRIOXACYCLODODECANE-3,7,11-TRIYL]TRIS(2,3-DIHYDROXYBENZAMIDE)'>EB4</scene>, <scene name='pdbligand=GA:GALLIUM+(III)+ION'>GA</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lbv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lbv OCA], [http://pdbe.org/2lbv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lbv RCSB], [http://www.ebi.ac.uk/pdbsum/2lbv PDBsum]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lbv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lbv OCA], [https://pdbe.org/2lbv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lbv RCSB], [https://www.ebi.ac.uk/pdbsum/2lbv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lbv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/EXFAB_COTJA EXFAB_COTJA]] Siderocalin-like lipocalin tightly binding a variety of bacterial ferric siderophores, also binds long-chain unsaturated fatty acids such as linoleic acid, oleic acid, arachidonic acid and, with a lower affinity, long chain saturated fatty acids such as steraic acid. May act as an antibacterial factor, through dual ligand specificity, both as a siderophore-sequestrating molecule and a lysophosphatidic acid (LPA) sensor.<ref>PMID:20826777</ref> <ref>PMID:21951132</ref>
+
[https://www.uniprot.org/uniprot/EXFAB_COTJA EXFAB_COTJA] Siderocalin-like lipocalin tightly binding a variety of bacterial ferric siderophores, also binds long-chain unsaturated fatty acids such as linoleic acid, oleic acid, arachidonic acid and, with a lower affinity, long chain saturated fatty acids such as steraic acid. May act as an antibacterial factor, through dual ligand specificity, both as a siderophore-sequestrating molecule and a lysophosphatidic acid (LPA) sensor.<ref>PMID:20826777</ref> <ref>PMID:21951132</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 19: Line 20:
==See Also==
==See Also==
-
*[[Fatty acid-binding protein|Fatty acid-binding protein]]
+
*[[Siderocalin 3D structures|Siderocalin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Cotja]]
+
[[Category: Coturnix japonica]]
-
[[Category: Bister, K]]
+
[[Category: Large Structures]]
-
[[Category: Coudevylle, N]]
+
[[Category: Bister K]]
-
[[Category: Geist, L]]
+
[[Category: Coudevylle N]]
-
[[Category: Hoetzinger, M]]
+
[[Category: Geist L]]
-
[[Category: Konrat, R]]
+
[[Category: Hoetzinger M]]
-
[[Category: Kontaxis, G]]
+
[[Category: Konrat R]]
-
[[Category: Arachidonic acid]]
+
[[Category: Kontaxis G]]
-
[[Category: Enterobactin]]
+
-
[[Category: Lipid transport]]
+
-
[[Category: Lipocalin]]
+
-
[[Category: Siderocalin]]
+

Current revision

Siderocalin Q83 reveals a dual ligand binding mode

PDB ID 2lbv

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2lbv"
Personal tools