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2lz5

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==Solution structure of a Novel Alpha-Conotoxin TxIB==
==Solution structure of a Novel Alpha-Conotoxin TxIB==
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<StructureSection load='2lz5' size='340' side='right' caption='[[2lz5]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2lz5' size='340' side='right'caption='[[2lz5]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2lz5]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LZ5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2lz5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_textile Conus textile]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LZ5 FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lz5 OCA], [http://pdbe.org/2lz5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lz5 RCSB], [http://www.ebi.ac.uk/pdbsum/2lz5 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lz5 OCA], [https://pdbe.org/2lz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lz5 RCSB], [https://www.ebi.ac.uk/pdbsum/2lz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lz5 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CA1B_CONTE CA1B_CONTE] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This conotoxin is a subtype-specific blocker of alpha-6/alpha-3-beta-2-beta-3 (CHRNA6/CHRNA3-CHRNB2-CHRNB3) nAChRs nicotinic acetylcholine receptors (nAChRs) (IC(50)=28.4 nM).<ref>PMID:23184959</ref> <ref>PMID:32235388</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Akcan, M]]
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[[Category: Conus textile]]
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[[Category: Christensen, S]]
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[[Category: Large Structures]]
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[[Category: Craik, D]]
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[[Category: Akcan M]]
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[[Category: Hu, Y]]
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[[Category: Christensen S]]
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[[Category: Luo, S]]
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[[Category: Craik D]]
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[[Category: McIntosh, J]]
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[[Category: Hu Y]]
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[[Category: McIntyre, M]]
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[[Category: Luo S]]
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[[Category: Wu, Y]]
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[[Category: McIntosh J]]
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[[Category: Zhangsun, D]]
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[[Category: McIntyre M]]
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[[Category: Zhu, X]]
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[[Category: Wu Y]]
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[[Category: Alpha-conotoxin]]
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[[Category: Zhangsun D]]
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[[Category: Alpha-helix]]
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[[Category: Zhu X]]
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[[Category: Amidated c-terminus]]
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[[Category: Disulfide bond]]
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[[Category: Toxin]]
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Current revision

Solution structure of a Novel Alpha-Conotoxin TxIB

PDB ID 2lz5

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