2mah

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==Solution structure of Smoothened==
==Solution structure of Smoothened==
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<StructureSection load='2mah' size='340' side='right' caption='[[2mah]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2mah' size='340' side='right'caption='[[2mah]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2mah]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MAH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2mah]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MAH FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">smo, CG11561 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mah OCA], [http://pdbe.org/2mah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mah RCSB], [http://www.ebi.ac.uk/pdbsum/2mah PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mah OCA], [https://pdbe.org/2mah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mah RCSB], [https://www.ebi.ac.uk/pdbsum/2mah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mah ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SMO_DROME SMO_DROME]] Segment polarity protein required for correct patterning of every segment. G protein-coupled receptor that associates with the patched protein (ptc) to transduce the hedgehog (hh) signal through the activation of an inhibitory G-protein. In the absence of hh, ptc represses the constitutive signaling activity of smo through fused (fu).
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[https://www.uniprot.org/uniprot/SMO_DROME SMO_DROME] Segment polarity protein required for correct patterning of every segment. G protein-coupled receptor that associates with the patched protein (ptc) to transduce the hedgehog (hh) signal through the activation of an inhibitory G-protein. In the absence of hh, ptc represses the constitutive signaling activity of smo through fused (fu).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Drome]]
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[[Category: Drosophila melanogaster]]
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[[Category: Lee, H]]
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[[Category: Large Structures]]
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[[Category: Rana, R]]
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[[Category: Lee H]]
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[[Category: Zheng, J J]]
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[[Category: Rana R]]
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[[Category: Hedgehog]]
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[[Category: Zheng JJ]]
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[[Category: Oncoprotein]]
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[[Category: Smoothened]]
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Current revision

Solution structure of Smoothened

PDB ID 2mah

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