NADP-dependent malic enzyme

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== Lysozyme ==
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<StructureSection load='3wja' size='340' side='right' caption='The best structure for NADP-dependent malic enzyme shown: [[3wja]]' scene=''>
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<StructureSection load='1swy' size='340' side='right' caption='Caption for this structure' scene=''>
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Best example is PDB entry [[3wja]] and is shown in the viewer.<br>
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Best example is 1swy<br>
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==Catalytic Activity ==
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Molecule Lysozyme, also known as Lysozyme, CP-7 lysin, Muramidase, Endolysin, 1,4-beta-N-acetylmuramidase, Lysis protein, CP-1 lysin, Lysozyme murein hydrolase, Protein gp17, Transglycosylase, Hevamine-A, Chitinase and L-alanyl-D-glutamate peptidase.
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Oxaloacetate = pyruvate + CO(2).Data source: Uniprot [http://www.uniprot.org/uniprot/P48163 P48163]<br>
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== Function ==
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Or the decarboxylation of malate to pyruvate<ref>PMID:8187880</ref>.
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lysozyme activity<br>
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catalytic activity<br>
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hydrolase activity<br>
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hydrolase activity, acting on glycosyl bonds<br>
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carbon-oxygen lyase activity, acting on polysaccharides<br>
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lyase activity<br>
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chitinase activity<br>
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hydrolase activity, hydrolyzing O-glycosyl compounds<br>
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sequence-specific DNA binding<br>
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== Disease ==
 
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{{#tree:id=test| openlevels=0|
 
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* top
 
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** second
 
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*** third
 
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}}
 
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== Relevance ==
 
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== Structural highlights ==
 
== Biological process ==
== Biological process ==
Is involved in the following biological processes:<br>
Is involved in the following biological processes:<br>
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cell wall macromolecule catabolic process<br>
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malate metabolic process<br>
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peptidoglycan catabolic process<br>
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oxidation-reduction process<br>
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metabolic process<br>
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response to carbohydrate<br>
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defense response to bacterium<br>
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response to hormone<br>
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cytolysis<br>
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viral release from host cell<br>
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carbohydrate metabolic process<br>
carbohydrate metabolic process<br>
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chitin catabolic process<br>
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protein tetramerization<br>
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polysaccharide catabolic process<br>
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regulation of NADP metabolic process<br>
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cytolysis by virus of host cell<br>
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NADP biosynthetic process<br>
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cell wall organization<br>
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small molecule metabolic process<br>
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cellular lipid metabolic process<br>
== In structures ==
== In structures ==
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Lysozyme is found in 595 PDB entries<br>
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NADP-dependent malic enzyme is found in 3 PDB entries<br>
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*<b>Eukaryota</b> (16 PDB entries): <br>
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*<b>Eukaryota</b> (3 PDB entries): <br>
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**<b>Homo sapiens</b> (1 PDB entries): <br>
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**<b>Homo sapiens</b> (2 PDB entries): <br>
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***[[4uis]] <div class="pdb-prints 4uis"></div>
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***[[3wja]] <div class="pdb-prints 3wja"></div>
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***Title: The cryoEM structure of human gamma-Secretase complex
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***Title: The crystal structure of human cytosolic NADP(+)-dependent malic enzyme in apo form
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***Experimental EM map [http://pdbe.org/emd-2974 emd-2974].
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***2.548 A resolution
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***4.4 A resolution
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***[http://www.ebi.ac.uk/pdbe/entry/search/index?organism_scientific_name:%22Homo%20sapiens%22&all_molecule_names:%22NADP-dependent%20malic%20enzyme%22&!chimera:y Search the PDB for NADP-dependent malic enzyme from Homo sapiens]
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***Other macromolecules also in this entry: GAMMA-SECRETASE, Nicastrin, Presenilin-1 NTF subunit, .
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**<b>Columba livia</b> (1 PDB entries): <br>
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**<b>Hevea brasiliensis</b> (7 PDB entries): <br>
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***[[1gq2]] <div class="pdb-prints 1gq2"></div>
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***[[1kqy]] <div class="pdb-prints 1kqy"></div>
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***Title: MALIC ENZYME FROM PIGEON LIVER
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***Title: Hevamine Mutant D125A/E127A/Y183F in Complex with Penta-NAG
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***1.92 A resolution
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***[http://www.ebi.ac.uk/pdbe/entry/search/index?organism_scientific:%34Hevea%20brasiliensis%34%20AND%20molecule_name:%34Lysozyme%34 Search for other PDB entries]
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**<b>Meretrix lusoria</b> (3 PDB entries): <br>
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***[[4pj2]] <div class="pdb-prints 4pj2"></div>
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***Title: Crystal structure of Aeromonas hydrophila PliI in complex with Meretrix lusoria lysozyme
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***1.24 A resolution
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***Other macromolecules also in this entry: Putative exported protein, .
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***[http://www.ebi.ac.uk/pdbe/entry/search/index?organism_scientific:%34Meretrix%20lusoria%34%20AND%20molecule_name:%34Lysozyme%34 Search for other PDB entries]
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**<b>Antheraea mylitta</b> (1 PDB entries): <br>
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***[[1iiz]] <div class="pdb-prints 1iiz"></div>
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***Title: Crystal Structure of the Induced Antibacterial Protein from Tasar Silkworm, Antheraea mylitta
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***2.4 A resolution
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**<b>Ruditapes philippinarum</b> (1 PDB entries): <br>
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***[[2dqa]] <div class="pdb-prints 2dqa"></div>
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***Title: Crystal Structure of Tapes japonica Lysozyme
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***1.6 A resolution
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**<b>Mus musculus</b> (1 PDB entries): <br>
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***[[1iak]] <div class="pdb-prints 1iak"></div>
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***Title: HISTOCOMPATIBILITY ANTIGEN I-AK
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***1.9 A resolution
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***Other macromolecules also in this entry: H-2 class II histocompatibility antigen, A-K beta chain, H-2 class II histocompatibility antigen, A-K alpha chain.
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**<b>Bombyx mori</b> (2 PDB entries): <br>
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***[[1gd6]] <div class="pdb-prints 1gd6"></div>
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***Title: STRUCTURE OF THE BOMBYX MORI LYSOZYME
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***2.5 A resolution
***2.5 A resolution
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***[http://www.ebi.ac.uk/pdbe/entry/search/index?organism_scientific:%34Bombyx%20mori%34%20AND%20molecule_name:%34Lysozyme%34 Search for other PDB entries]
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== Alternative names for NADP-dependent malic enzyme ==
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*<b>Viruses</b> (578 PDB entries): <br>
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Molecule '''NADP-dependent malic enzyme''', also known as '''NADP-ME''', '''NADP-dependent malic enzyme''' and '''Malic enzyme 1'''.
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**<b>Enterobacteria phage P22</b> (2 PDB entries): <br>
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***[[2anv]] <div class="pdb-prints 2anv"></div>
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== 3D Structures of NADP-dependent malic enzyme ==
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***Title: crystal structure of P22 lysozyme mutant L86M
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***1.04 A resolution
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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***[http://www.ebi.ac.uk/pdbe/entry/search/index?organism_scientific:%34Enterobacteria%20phage%20P22%34%20AND%20molecule_name:%34Lysozyme%34 Search for other PDB entries]
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**<b>Enterobacteria phage P21</b> (2 PDB entries): <br>
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***[[3hdf]] <div class="pdb-prints 3hdf"></div>
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[[3wja]], [[2aw5]] – hME - human<br />
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***Title: Crystal structure of truncated endolysin R21 from phage 21
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[[7x11]], [[7x12]] – hME1 + NADP<br />
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***1.7 A resolution
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[[8e76]], [[8eyn]] – hME3<br />
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***[http://www.ebi.ac.uk/pdbe/entry/search/index?organism_scientific:%34Enterobacteria%20phage%20P21%34%20AND%20molecule_name:%34Lysozyme%34 Search for other PDB entries]
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[[8e78]], [[8e8o]], [[8eyo]] – hME3 + NADP<br />
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**<b>Enterobacteria phage T4</b> (561 PDB entries): <br>
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[[1gq2]] – ME + NADP - pigeon<br />
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***[[1swy]] <div class="pdb-prints 1swy"></div>
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[[5ou5]] – ME - maize<br />
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***Title: Use of a Halide Binding Site to Bypass the 1000-atom Limit to Ab initio Structure Determination
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***1.06 A resolution
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== References ==
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***[http://www.ebi.ac.uk/pdbe/entry/search/index?organism_scientific:%34Enterobacteria%20phage%20T4%34%20AND%20molecule_name:%34Lysozyme%34 Search for other PDB entries]
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<references/>
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**<b>Escherichia phage T5</b> (1 PDB entries): <br>
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[[Category:Topic Page]][[Category:PDBe]]
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***[[2mxz]] <div class="pdb-prints 2mxz"></div>
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***Title: Bacteriophage T5 l-alanoyl-d-glutamate peptidase comlpex with Zn2+ (Endo T5-ZN2+)
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***N/A A resolution
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**<b>Enterobacteria phage lambda</b> (3 PDB entries): <br>
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***[[1am7]] <div class="pdb-prints 1am7"></div>
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***Title: Lysozyme from bacteriophage lambda
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***2.3 A resolution
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***[http://www.ebi.ac.uk/pdbe/entry/search/index?organism_scientific:%34Enterobacteria%20phage%20lambda%34%20AND%20molecule_name:%34Lysozyme%34 Search for other PDB entries]
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**<b>Streptococcus phage CP-7</b> (1 PDB entries): <br>
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***[[4cvd]] <div class="pdb-prints 4cvd"></div>
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***Title: Crystal structure of the central repeat of cell wall binding module of Cpl7
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***1.666 A resolution
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**<b>Enterobacteria phage P1</b> (2 PDB entries): <br>
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***[[1xju]] <div class="pdb-prints 1xju"></div>
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***Title: Crystal structure of secreted inactive form of P1 phage endolysin Lyz
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***1.07 A resolution
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***[http://www.ebi.ac.uk/pdbe/entry/search/index?organism_scientific:%34Enterobacteria%20phage%20P1%34%20AND%20molecule_name:%34Lysozyme%34 Search for other PDB entries]
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**<b>Streptococcus phage Cp-1</b> (6 PDB entries): <br>
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***[[2j8g]] <div class="pdb-prints 2j8g"></div>
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***Title: Crystal structure of the modular Cpl-1 endolysin complexed with a peptidoglycan analogue (E94Q mutant in complex with a tetrasaccharide- pentapeptide)
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***1.69 A resolution
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***[http://www.ebi.ac.uk/pdbe/entry/search/index?organism_scientific:%34Streptococcus%20phage%20Cp-1%34%20AND%20molecule_name:%34Lysozyme%34 Search for other PDB entries]
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*<b>Bacteria</b> (1 PDB entries): <br>
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**<b>Enterobacteria phage T4</b> (1 PDB entries): <br>
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***[[2qb0]] <div class="pdb-prints 2qb0"></div>
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***Title: Structure of the 2TEL crystallization module fused to T4 lysozyme with an Ala-Gly-Pro linker.
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***2.56 A resolution
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***Other macromolecules also in this entry: Transcription factor ETV6, .
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**<b>Escherichia coli</b> (1 PDB entries): <br>
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***[[2qb0]] <div class="pdb-prints 2qb0"></div>
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***Title: Structure of the 2TEL crystallization module fused to T4 lysozyme with an Ala-Gly-Pro linker.
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***2.56 A resolution
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***Other macromolecules also in this entry: Transcription factor ETV6, .
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Current revision

The best structure for NADP-dependent malic enzyme shown: 3wja

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Proteopedia Page Contributors and Editors (what is this?)

PDBe, Jaime Prilusky, Michal Harel

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