1hkf

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==THE THREE DIMENSIONAL STRUCTURE OF NK CELL RECEPTOR NKP44, A TRIGGERING PARTNER IN NATURAL CYTOTOXICITY==
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<StructureSection load='1hkf' size='340' side='right' caption='[[1hkf]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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==The three dimensional structure of NK cell receptor Nkp44, a triggering partner in natural cytotoxicity==
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<StructureSection load='1hkf' size='340' side='right'caption='[[1hkf]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1hkf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HKF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HKF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1hkf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HKF FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hkf OCA], [http://pdbe.org/1hkf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hkf RCSB], [http://www.ebi.ac.uk/pdbsum/1hkf PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hkf OCA], [https://pdbe.org/1hkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hkf RCSB], [https://www.ebi.ac.uk/pdbsum/1hkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hkf ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NCTR2_HUMAN NCTR2_HUMAN] Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.<ref>PMID:10049942</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hk/1hkf_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hk/1hkf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hkf ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Biassoni, R]]
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[[Category: Large Structures]]
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[[Category: Bolognesi, M]]
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[[Category: Biassoni R]]
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[[Category: Bordo, D]]
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[[Category: Bolognesi M]]
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[[Category: Cantoni, C]]
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[[Category: Bordo D]]
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[[Category: Conte, R]]
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[[Category: Cantoni C]]
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[[Category: Moretta, A]]
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[[Category: Conte R]]
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[[Category: Moretta, L]]
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[[Category: Moretta A]]
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[[Category: Ponassi, M]]
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[[Category: Moretta L]]
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[[Category: Spallarossa, A]]
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[[Category: Ponassi M]]
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[[Category: Immunoglobulin domain]]
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[[Category: Spallarossa A]]
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[[Category: Natural cytotoxicity receptor]]
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[[Category: Nkp44]]
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[[Category: Receptor]]
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Current revision

The three dimensional structure of NK cell receptor Nkp44, a triggering partner in natural cytotoxicity

PDB ID 1hkf

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