2jhs

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==CRYSTAL STRUCTURE OF RHOGDI K135H,K138H,K141H MUTANT==
==CRYSTAL STRUCTURE OF RHOGDI K135H,K138H,K141H MUTANT==
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<StructureSection load='2jhs' size='340' side='right' caption='[[2jhs]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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<StructureSection load='2jhs' size='340' side='right'caption='[[2jhs]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2jhs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JHS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JHS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2jhs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JHS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cc0|1cc0]], [[1fso|1fso]], [[1fst|1fst]], [[1ft0|1ft0]], [[1ft3|1ft3]], [[1hh4|1hh4]], [[1kmt|1kmt]], [[1qvy|1qvy]], [[1rho|1rho]], [[2bxw|2bxw]], [[2jht|2jht]], [[2jhu|2jhu]], [[2jhv|2jhv]], [[2jhw|2jhw]], [[2jhx|2jhx]], [[2jhy|2jhy]], [[2jhz|2jhz]], [[2ji0|2ji0]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jhs OCA], [http://pdbe.org/2jhs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jhs RCSB], [http://www.ebi.ac.uk/pdbsum/2jhs PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jhs OCA], [https://pdbe.org/2jhs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jhs RCSB], [https://www.ebi.ac.uk/pdbsum/2jhs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jhs ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GDIR1_HUMAN GDIR1_HUMAN] Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1 (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jh/2jhs_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jh/2jhs_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jhs ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Cooper, D R]]
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[[Category: Large Structures]]
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[[Category: Derewenda, Z S]]
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[[Category: Cooper DR]]
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[[Category: Zawadzki, M]]
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[[Category: Derewenda ZS]]
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[[Category: Crystal engineering]]
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[[Category: Zawadzki M]]
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[[Category: Gtpase activation]]
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[[Category: Inhibitor]]
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[[Category: Surface entropy reduction]]
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Current revision

CRYSTAL STRUCTURE OF RHOGDI K135H,K138H,K141H MUTANT

PDB ID 2jhs

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