This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2m3d

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (05:58, 15 May 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
 +
==NMR structure of the GUCT domain from human DEAD box polypeptide 21==
==NMR structure of the GUCT domain from human DEAD box polypeptide 21==
-
<StructureSection load='2m3d' size='340' side='right' caption='[[2m3d]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+
<StructureSection load='2m3d' size='340' side='right'caption='[[2m3d]]' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2m3d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M3D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M3D FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2m3d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M3D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M3D FirstGlance]. <br>
-
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DDX21 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA_helicase RNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.13 3.6.4.13] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m3d OCA], [https://pdbe.org/2m3d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m3d RCSB], [https://www.ebi.ac.uk/pdbsum/2m3d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m3d ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m3d OCA], [http://pdbe.org/2m3d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m3d RCSB], [http://www.ebi.ac.uk/pdbsum/2m3d PDBsum]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/DDX21_HUMAN DDX21_HUMAN]] RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Involved in rRNA processing (PubMed:14559904, PubMed:18180292).<ref>PMID:11823437</ref> <ref>PMID:14559904</ref> <ref>PMID:18180292</ref> <ref>PMID:25260534</ref> <ref>PMID:25470060</ref> <ref>PMID:25477391</ref> <ref>PMID:9461305</ref>
+
[https://www.uniprot.org/uniprot/DDX21_HUMAN DDX21_HUMAN] RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Involved in rRNA processing (PubMed:14559904, PubMed:18180292).<ref>PMID:11823437</ref> <ref>PMID:14559904</ref> <ref>PMID:18180292</ref> <ref>PMID:25260534</ref> <ref>PMID:25470060</ref> <ref>PMID:25477391</ref> <ref>PMID:9461305</ref>
==See Also==
==See Also==
-
*[[Helicase|Helicase]]
+
*[[Helicase 3D structures|Helicase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
-
[[Category: RNA helicase]]
+
[[Category: Large Structures]]
-
[[Category: Dutta, S K]]
+
[[Category: Dutta SK]]
-
[[Category: Geralt, M]]
+
[[Category: Geralt M]]
-
[[Category: Structural genomic]]
+
[[Category: Serrano P]]
-
[[Category: Serrano, P]]
+
[[Category: Wuthrich K]]
-
[[Category: TCELL, Partnership for T-Cell Biology]]
+
-
[[Category: Wuthrich, K]]
+
-
[[Category: Guct domain]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Rrm fold]]
+

Current revision

NMR structure of the GUCT domain from human DEAD box polypeptide 21

PDB ID 2m3d

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2m3d"
Personal tools