1y7n

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==Solution structure of the second PDZ domain of the human neuronal adaptor X11alpha==
==Solution structure of the second PDZ domain of the human neuronal adaptor X11alpha==
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<StructureSection load='1y7n' size='340' side='right' caption='[[1y7n]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='1y7n' size='340' side='right'caption='[[1y7n]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1y7n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y7N FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1y7n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y7N FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">APBA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7n OCA], [http://pdbe.org/1y7n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1y7n RCSB], [http://www.ebi.ac.uk/pdbsum/1y7n PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y7n OCA], [https://pdbe.org/1y7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y7n RCSB], [https://www.ebi.ac.uk/pdbsum/1y7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y7n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/APBA1_HUMAN APBA1_HUMAN]] Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.
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[https://www.uniprot.org/uniprot/APBA1_HUMAN APBA1_HUMAN] Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y7/1y7n_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y7/1y7n_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y7n ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Brouwer, J]]
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[[Category: Large Structures]]
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[[Category: Canters, G W]]
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[[Category: Brouwer J]]
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[[Category: Drijfhout, J W]]
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[[Category: Canters GW]]
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[[Category: Duquesne, A E]]
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[[Category: Drijfhout JW]]
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[[Category: Nabuurs, S B]]
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[[Category: Duquesne AE]]
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[[Category: Ruijter, M de]]
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[[Category: Nabuurs SB]]
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[[Category: Spronk, C A.E M]]
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[[Category: Spronk CAEM]]
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[[Category: Ubbink, M]]
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[[Category: Ubbink M]]
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[[Category: Vuister, G W]]
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[[Category: Vuister GW]]
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[[Category: Copper chaperone for superoxide dismutase]]
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[[Category: De Ruijter M]]
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[[Category: Neuronal adaptor]]
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[[Category: Protein transport]]
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Current revision

Solution structure of the second PDZ domain of the human neuronal adaptor X11alpha

PDB ID 1y7n

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