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2ltp

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==Solution structure of the SANT2 domain of the human nuclear receptor corepressor 2 (NCoR2), Northeast Structural Genomics Consortium (NESG) target ID HR4636E==
==Solution structure of the SANT2 domain of the human nuclear receptor corepressor 2 (NCoR2), Northeast Structural Genomics Consortium (NESG) target ID HR4636E==
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<StructureSection load='2ltp' size='340' side='right' caption='[[2ltp]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2ltp' size='340' side='right'caption='[[2ltp]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ltp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LTP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LTP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ltp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LTP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LTP FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NCOR2, CTG26 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ltp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ltp OCA], [http://pdbe.org/2ltp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ltp RCSB], [http://www.ebi.ac.uk/pdbsum/2ltp PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ltp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ltp OCA], [https://pdbe.org/2ltp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ltp RCSB], [https://www.ebi.ac.uk/pdbsum/2ltp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ltp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NCOR2_HUMAN NCOR2_HUMAN]] Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors.
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[https://www.uniprot.org/uniprot/NCOR2_HUMAN NCOR2_HUMAN] Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors.
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==See Also==
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*[[Nuclear receptor corepressor|Nuclear receptor corepressor]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C]]
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[[Category: Large Structures]]
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[[Category: Bellanda, M]]
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[[Category: Arrowsmith C]]
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[[Category: Garcia, M]]
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[[Category: Bellanda M]]
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[[Category: Houliston, S]]
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[[Category: Garcia M]]
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[[Category: Lemak, A]]
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[[Category: Houliston S]]
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[[Category: Min, J]]
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[[Category: Lemak A]]
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[[Category: Montecchio, M]]
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[[Category: Min J]]
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[[Category: Montelione, G T]]
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[[Category: Montecchio M]]
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[[Category: Structural genomic]]
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[[Category: Montelione GT]]
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[[Category: Xu, C]]
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[[Category: Xu C]]
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[[Category: Yee, A]]
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[[Category: Yee A]]
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[[Category: Nesg]]
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[[Category: Sgc]]
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[[Category: Smrt]]
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[[Category: Trac]]
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[[Category: Transcription regulator]]
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Current revision

Solution structure of the SANT2 domain of the human nuclear receptor corepressor 2 (NCoR2), Northeast Structural Genomics Consortium (NESG) target ID HR4636E

PDB ID 2ltp

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