2a1y

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[[Image:2a1y.gif|left|200px]]
 
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{{Structure
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==Crystal Structure of GuaC-GMP complex from Bacillus anthracis at 2.26 A Resolution.==
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|PDB= 2a1y |SIZE=350|CAPTION= <scene name='initialview01'>2a1y</scene>, resolution 2.27&Aring;
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<StructureSection load='2a1y' size='340' side='right'caption='[[2a1y]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=5GP:GUANOSINE-5&#39;-MONOPHOSPHATE'>5GP</scene>
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<table><tr><td colspan='2'>[[2a1y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A1Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A1Y FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/GMP_reductase GMP reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.1.7 1.7.1.7]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.27&#8491;</td></tr>
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|GENE= guaC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 Bacillus anthracis])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a1y OCA], [https://pdbe.org/2a1y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a1y RCSB], [https://www.ebi.ac.uk/pdbsum/2a1y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a1y ProSAT]</span></td></tr>
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</table>
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'''Crystal Structure of GuaC-GMP complex from Bacillus anthracis at 2.26 A Resolution.'''
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== Function ==
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[https://www.uniprot.org/uniprot/GUAC_BACAN GUAC_BACAN] Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity).
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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2A1Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A1Y OCA].
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a1/2a1y_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a1y ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Bacillus anthracis]]
[[Category: Bacillus anthracis]]
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[[Category: GMP reductase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Blagova EV]]
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[[Category: Blagova, E V.]]
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[[Category: Brannigan JA]]
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[[Category: Brannigan, J A.]]
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[[Category: Fogg MJ]]
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[[Category: Fogg, M J.]]
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[[Category: Grenha R]]
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[[Category: Grenha, R.]]
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[[Category: Levdikov VM]]
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[[Category: Levdikov, V M.]]
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[[Category: Wilkinson AJ]]
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[[Category: SPINE, Structural Proteomics in Europe.]]
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[[Category: Wilson KS]]
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[[Category: Wilkinson, A J.]]
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[[Category: Wilson, K S.]]
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[[Category: 5GP]]
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[[Category: and nucleotides: nucleotide and nucleoside interconversion]]
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[[Category: gmp]]
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[[Category: guac]]
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[[Category: nucleoside]]
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[[Category: purine]]
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[[Category: pyrimidine]]
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[[Category: spine]]
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[[Category: structural genomic]]
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[[Category: structural proteomics in europe]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 14:34:03 2008''
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Current revision

Crystal Structure of GuaC-GMP complex from Bacillus anthracis at 2.26 A Resolution.

PDB ID 2a1y

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