1i2l
From Proteopedia
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==DEOXYCHORISMATE LYASE FROM ESCHERICHIA COLI WITH INHIBITOR== | ==DEOXYCHORISMATE LYASE FROM ESCHERICHIA COLI WITH INHIBITOR== | ||
| - | <StructureSection load='1i2l' size='340' side='right' caption='[[1i2l]], [[Resolution|resolution]] 2.30Å' scene=''> | + | <StructureSection load='1i2l' size='340' side='right'caption='[[1i2l]], [[Resolution|resolution]] 2.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1i2l]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1i2l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I2L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I2L FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DCS:D-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-N,O-CYCLOSERYLAMIDE'>DCS</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i2l OCA], [https://pdbe.org/1i2l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i2l RCSB], [https://www.ebi.ac.uk/pdbsum/1i2l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i2l ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/PABC_ECOLI PABC_ECOLI] Involved in the biosynthesis of p-aminobenzoate (PABA), a precursor of tetrahydrofolate. Converts 4-amino-4-deoxychorismate into 4-aminobenzoate (PABA) and pyruvate.<ref>PMID:1644759</ref> <ref>PMID:2251281</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i2/1i2l_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i2/1i2l_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1i2l ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
== References == | == References == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Escherichia coli]] |
| - | [[Category: Eisenstein | + | [[Category: Large Structures]] |
| - | [[Category: Fisher | + | [[Category: Eisenstein E]] |
| - | [[Category: Howard | + | [[Category: Fisher KE]] |
| - | [[Category: Jensen | + | [[Category: Howard AJ]] |
| - | [[Category: Ladner | + | [[Category: Jensen PY]] |
| - | [[Category: Pachikara | + | [[Category: Ladner JE]] |
| - | [[Category: Parsons | + | [[Category: Pachikara AS]] |
| - | [[Category: Tordova | + | [[Category: Parsons JF]] |
| - | + | [[Category: Tordova M]] | |
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Current revision
DEOXYCHORISMATE LYASE FROM ESCHERICHIA COLI WITH INHIBITOR
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