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2nvj

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==NMR structures of transmembrane segment from subunit a from the yeast proton V-ATPase==
==NMR structures of transmembrane segment from subunit a from the yeast proton V-ATPase==
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<StructureSection load='2nvj' size='340' side='right' caption='[[2nvj]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2nvj' size='340' side='right'caption='[[2nvj]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2nvj]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NVJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NVJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2nvj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NVJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NVJ FirstGlance]. <br>
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</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/H(+)-transporting_two-sector_ATPase H(+)-transporting two-sector ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.14 3.6.3.14] </span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nvj OCA], [http://pdbe.org/2nvj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nvj RCSB], [http://www.ebi.ac.uk/pdbsum/2nvj PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nvj OCA], [https://pdbe.org/2nvj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nvj RCSB], [https://www.ebi.ac.uk/pdbsum/2nvj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nvj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/VPH1_YEAST VPH1_YEAST]] Subunit of the integral membrane V0 complex of vacuolar ATPase essential for assembly and catalytic activity. Is present only in vacuolar V-ATPase complexes. Enzymes containing this subunit have a 4-fold higher ratio of proton transport to ATP hydrolysis than complexes containing the Golgi/endosomal isoform and undergo reversible dissociation of V1 and V0 in response to glucose depletion. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.<ref>PMID:11278748</ref> <ref>PMID:1491220</ref> <ref>PMID:8798414</ref>
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[https://www.uniprot.org/uniprot/VPP1_YEAST VPP1_YEAST] Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:1491220, PubMed:8798414, PubMed:11278748). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:1491220, PubMed:11278748). Is present only in vacuolar V-ATPase complexes; enzymes containing this subunit have a 4-fold higher ratio of proton transport to ATP hydrolysis than complexes containing the Golgi/endosomal isoform and undergo reversible dissociation of V1 and V0 in response to glucose depletion (PubMed:8798414, PubMed:11278748).<ref>PMID:11278748</ref> <ref>PMID:1491220</ref> <ref>PMID:8798414</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 2nvj" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2nvj" style="background-color:#fffaf0;"></div>
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==See Also==
 
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*[[V-ATPase|V-ATPase]]
 
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Duarte, A M]]
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[[Category: Large Structures]]
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[[Category: Hemminga, M A]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Jong, E R.de]]
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[[Category: Duarte AM]]
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[[Category: Mierlo, C P.van]]
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[[Category: Hemminga MA]]
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[[Category: Wechselberger, R]]
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[[Category: Wechselberger R]]
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[[Category: 10 helix]]
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[[Category: De Jong ER]]
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[[Category: Alfa helix]]
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[[Category: Van Mierlo CP]]
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[[Category: Hydrolase]]
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[[Category: Pi helix]]
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Current revision

NMR structures of transmembrane segment from subunit a from the yeast proton V-ATPase

PDB ID 2nvj

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