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2f2b

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==Crystal structure of integral membrane protein Aquaporin AqpM at 1.68A resolution==
==Crystal structure of integral membrane protein Aquaporin AqpM at 1.68A resolution==
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<StructureSection load='2f2b' size='340' side='right' caption='[[2f2b]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
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<StructureSection load='2f2b' size='340' side='right'caption='[[2f2b]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2f2b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mettm Mettm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F2B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F2B FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2f2b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermobacter_marburgensis_str._Marburg Methanothermobacter marburgensis str. Marburg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F2B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F2B FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2evu|2evu]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">aqpM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=79929 METTM])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f2b OCA], [https://pdbe.org/2f2b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f2b RCSB], [https://www.ebi.ac.uk/pdbsum/2f2b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f2b ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f2b OCA], [http://pdbe.org/2f2b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2f2b RCSB], [http://www.ebi.ac.uk/pdbsum/2f2b PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AQPM_METTM AQPM_METTM]] Channel that permits osmotically driven movement of water in both directions. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity. Exhibits also a transient but reproducible increase in the initial glycerol flux.
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[https://www.uniprot.org/uniprot/AQPM_METTM AQPM_METTM] Channel that permits osmotically driven movement of water in both directions. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity. Exhibits also a transient but reproducible increase in the initial glycerol flux.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f2/2f2b_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f2/2f2b_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f2b ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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==See Also==
==See Also==
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*[[Aquaporin|Aquaporin]]
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*[[Aquaporin 3D structures|Aquaporin 3D structures]]
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*[[Nobel Prizes for 3D Molecular Structure|Nobel Prizes for 3D Molecular Structure]]
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Mettm]]
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[[Category: Large Structures]]
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[[Category: Agre, P]]
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[[Category: Methanothermobacter marburgensis str. Marburg]]
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[[Category: CSMP, Center for Structures of Membrane Proteins]]
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[[Category: Agre P]]
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[[Category: Kitagawa, Y]]
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[[Category: Kitagawa Y]]
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[[Category: Kozono, D]]
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[[Category: Kozono D]]
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[[Category: Lee, J K]]
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[[Category: Lee JK]]
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[[Category: Remis, J]]
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[[Category: Remis J]]
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[[Category: Stroud, R M]]
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[[Category: Stroud RM]]
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[[Category: Center for structures of membrane protein]]
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[[Category: Channel]]
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[[Category: Csmp]]
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[[Category: Integral membrane protein]]
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[[Category: Membrane protein]]
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[[Category: Protein]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Structural genomic]]
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Current revision

Crystal structure of integral membrane protein Aquaporin AqpM at 1.68A resolution

PDB ID 2f2b

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