1kll

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==Molecular basis of mitomycin C resictance in streptomyces: Crystal structures of the MRD protein with and without a drug derivative==
==Molecular basis of mitomycin C resictance in streptomyces: Crystal structures of the MRD protein with and without a drug derivative==
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<StructureSection load='1kll' size='340' side='right' caption='[[1kll]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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<StructureSection load='1kll' size='340' side='right'caption='[[1kll]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1kll]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_lavendulae"_waksman_and_curtis_1916 "actinomyces lavendulae" waksman and curtis 1916]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KLL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KLL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1kll]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_lavendulae Streptomyces lavendulae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KLL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KLL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MC:1,2-CIS-1-HYDROXY-2,7-DIAMINO-MITOSENE'>MC</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MC:1,2-CIS-1-HYDROXY-2,7-DIAMINO-MITOSENE'>MC</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1kmz|1kmz]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kll OCA], [https://pdbe.org/1kll PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kll RCSB], [https://www.ebi.ac.uk/pdbsum/1kll PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kll ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kll OCA], [http://pdbe.org/1kll PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kll RCSB], [http://www.ebi.ac.uk/pdbsum/1kll PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O05205_STRLA O05205_STRLA]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kl/1kll_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kl/1kll_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kll ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Actinomyces lavendulae waksman and curtis 1916]]
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[[Category: Large Structures]]
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[[Category: Dauter, Z]]
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[[Category: Streptomyces lavendulae]]
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[[Category: Derewenda, U]]
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[[Category: Dauter Z]]
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[[Category: Derewenda, Z S]]
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[[Category: Derewenda U]]
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[[Category: Devedjiev, Y]]
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[[Category: Derewenda ZS]]
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[[Category: He, M]]
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[[Category: Devedjiev Y]]
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[[Category: Jelen, F]]
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[[Category: He M]]
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[[Category: Martin, T W]]
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[[Category: Jelen F]]
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[[Category: Otlewski, J]]
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[[Category: Martin TW]]
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[[Category: Sheffield, P]]
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[[Category: Otlewski J]]
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[[Category: Sherman, D]]
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[[Category: Sheffield P]]
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[[Category: Anomalous diffraction]]
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[[Category: Sherman D]]
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[[Category: Antibiotic resistance]]
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[[Category: Antimicrobial protein]]
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[[Category: Domain swapping]]
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[[Category: Mitomycin c]]
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[[Category: P-staking]]
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[[Category: Sad]]
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Current revision

Molecular basis of mitomycin C resictance in streptomyces: Crystal structures of the MRD protein with and without a drug derivative

PDB ID 1kll

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