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2on8

From Proteopedia

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==Gbeta1 stabilization by in vitro evolution and computational design==
==Gbeta1 stabilization by in vitro evolution and computational design==
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<StructureSection load='2on8' size='340' side='right' caption='[[2on8]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
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<StructureSection load='2on8' size='340' side='right'caption='[[2on8]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2on8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_g148 Streptococcus g148]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ON8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ON8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2on8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_sp._G148 Streptococcus sp. G148]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ON8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ON8 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1pga|1pga]], [[1pgb|1pgb]], [[1gb4|1gb4]], [[1fcc|1fcc]], [[3gb1|3gb1]], [[1p7e|1p7e]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">spg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1324 Streptococcus G148])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2on8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2on8 OCA], [https://pdbe.org/2on8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2on8 RCSB], [https://www.ebi.ac.uk/pdbsum/2on8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2on8 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2on8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2on8 OCA], [http://pdbe.org/2on8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2on8 RCSB], [http://www.ebi.ac.uk/pdbsum/2on8 PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPG2_STRSG SPG2_STRSG]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/on/2on8_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/on/2on8_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2on8 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Streptococcus g148]]
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[[Category: Large Structures]]
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[[Category: Heinemann, U]]
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[[Category: Streptococcus sp. G148]]
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[[Category: Max, K E.A]]
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[[Category: Heinemann U]]
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[[Category: Alpha helix]]
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[[Category: Max KEA]]
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[[Category: Beta sheet]]
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[[Category: Improved hydrophobic packing of core residue]]
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[[Category: Protein binding]]
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Current revision

Gbeta1 stabilization by in vitro evolution and computational design

PDB ID 2on8

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